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- W2023381279 abstract "Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL)1β, 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon-γ, and tumour necrosis factor-α, measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial. Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR=1.68, 95% CI=1.13–2.49), whereas decreased IL-1β or IL-10 reduced the risk of advanced adenoma recurrence (OR=0.37, 95% CI=0.15–0.94; OR=0.39, 95% CI=0.15–0.98, respectively). Individuals with flavonol intake above the median (29.7 mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence. Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms." @default.
- W2023381279 created "2016-06-24" @default.
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- W2023381279 date "2010-10-01" @default.
- W2023381279 modified "2023-10-10" @default.
- W2023381279 title "Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial" @default.
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- W2023381279 doi "https://doi.org/10.1038/sj.bjc.6605915" @default.
- W2023381279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2990604" @default.
- W2023381279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20924374" @default.
- W2023381279 hasPublicationYear "2010" @default.
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