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• W2023382528 endingPage "e1000654" @default.
• W2023382528 startingPage "e1000654" @default.
• W2023382528 abstract "Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that employs several unique strategies for gene expression. The shortest transcript of BDV, X/P mRNA, encodes at least three open reading frames (ORFs): upstream ORF (uORF), X, and P in the 5′ to 3′ direction. The X is a negative regulator of viral polymerase activity, while the P phosphoprotein is a necessary cofactor of the polymerase complex, suggesting that the translation of X is controlled rigorously, depending on viral replication. However, the translation mechanism used by the X/P polycistronic mRNA has not been determined in detail. Here we demonstrate that the X/P mRNA autogenously regulates the translation of X via interaction with host factors. Transient transfection of cDNA clones corresponding to the X/P mRNA revealed that the X ORF is translated predominantly by uORF-termination-coupled reinitiation, the efficiency of which is upregulated by expression of P. We found that P may enhance ribosomal reinitiation at the X ORF by inhibition of the interaction of the DEAD-box RNA helicase DDX21 with the 5′ untranslated region of X/P mRNA, via interference with its phosphorylation. Our results not only demonstrate a unique translational control of viral regulatory protein, but also elucidate a previously unknown mechanism of regulation of polycistronic mRNA translation using RNA helicases." @default.
• W2023382528 created "2016-06-24" @default.
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• W2023382528 creator A5062955704 @default.
• W2023382528 date "2009-11-06" @default.
• W2023382528 modified "2023-10-17" @default.
• W2023382528 title "Autogenous Translational Regulation of the Borna Disease Virus Negative Control Factor X from Polycistronic mRNA Using Host RNA Helicases" @default.
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• W2023382528 doi "https://doi.org/10.1371/journal.ppat.1000654" @default.
• W2023382528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2766071" @default.
• W2023382528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19893625" @default.
• W2023382528 hasPublicationYear "2009" @default.
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