Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023385492> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2023385492 endingPage "109" @default.
- W2023385492 startingPage "103" @default.
- W2023385492 abstract "Age-associated changes in liver injury and post-necrotic regeneration were studied in rats aged 6 and 30 months in a period of 96 h following a dose of thioacetamide (6.6 mmol/kg body weight). Hepatocellular necrosis was detected in both groups by serum aspartate aminotransferase, but the severity of injury was significantly lower (one fourth, p < 0.001) in the oldest. Differences were observed in hepatocyte FAD monooxygenase activity between 6 and 30 months old rats at 24 h (278 versus 170%, p < 0.001, respectively) and also in GSH/GSSG ratio, in protein thiol groups and in malondialdehyde. Glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase activities rose markedly in both groups, this increase being slightly lower in the oldest. Superoxide dismutase and catalase did not show significant changes between both groups. At the end of the 96 h experimental period the restoration towards normal of GSG/GSSG, protein thiols malondialdehyde and the activities of Cu-Zn superoxide dismutase and catalase were significantly lower in hepatocytes from 30 months old rats. We summarize that the main age-related changes in the sequenced process of liver injury and regeneration occurred to a lesser extent in severity of injury and delayed response in the post-necrotic restoration of liver function, probably due to a lower increase in antioxidant enzyme system." @default.
- W2023385492 created "2016-06-24" @default.
- W2023385492 creator A5013231346 @default.
- W2023385492 creator A5034846300 @default.
- W2023385492 creator A5077764389 @default.
- W2023385492 date "1998-01-01" @default.
- W2023385492 modified "2023-10-02" @default.
- W2023385492 title "Aging delays the post‐necrotic restoration of liver function" @default.
- W2023385492 cites W1508875062 @default.
- W2023385492 cites W1557322059 @default.
- W2023385492 cites W1774165831 @default.
- W2023385492 cites W1975333022 @default.
- W2023385492 cites W1976681427 @default.
- W2023385492 cites W1978018003 @default.
- W2023385492 cites W1987860354 @default.
- W2023385492 cites W2002634680 @default.
- W2023385492 cites W2002719814 @default.
- W2023385492 cites W2027262109 @default.
- W2023385492 cites W2085396235 @default.
- W2023385492 cites W2169162593 @default.
- W2023385492 cites W2497129786 @default.
- W2023385492 cites W4255271863 @default.
- W2023385492 cites W4293247451 @default.
- W2023385492 doi "https://doi.org/10.1002/biof.5520080118" @default.
- W2023385492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9699017" @default.
- W2023385492 hasPublicationYear "1998" @default.
- W2023385492 type Work @default.
- W2023385492 sameAs 2023385492 @default.
- W2023385492 citedByCount "8" @default.
- W2023385492 countsByYear W20233854922013 @default.
- W2023385492 crossrefType "journal-article" @default.
- W2023385492 hasAuthorship W2023385492A5013231346 @default.
- W2023385492 hasAuthorship W2023385492A5034846300 @default.
- W2023385492 hasAuthorship W2023385492A5077764389 @default.
- W2023385492 hasConcept C126322002 @default.
- W2023385492 hasConcept C134018914 @default.
- W2023385492 hasConcept C165069038 @default.
- W2023385492 hasConcept C16685009 @default.
- W2023385492 hasConcept C181199279 @default.
- W2023385492 hasConcept C185592680 @default.
- W2023385492 hasConcept C202751555 @default.
- W2023385492 hasConcept C2775838275 @default.
- W2023385492 hasConcept C2776200302 @default.
- W2023385492 hasConcept C2776637226 @default.
- W2023385492 hasConcept C2778004101 @default.
- W2023385492 hasConcept C2778248901 @default.
- W2023385492 hasConcept C2778401633 @default.
- W2023385492 hasConcept C2778760513 @default.
- W2023385492 hasConcept C2778979269 @default.
- W2023385492 hasConcept C2781057625 @default.
- W2023385492 hasConcept C2992208098 @default.
- W2023385492 hasConcept C538909803 @default.
- W2023385492 hasConcept C55493867 @default.
- W2023385492 hasConcept C71924100 @default.
- W2023385492 hasConceptScore W2023385492C126322002 @default.
- W2023385492 hasConceptScore W2023385492C134018914 @default.
- W2023385492 hasConceptScore W2023385492C165069038 @default.
- W2023385492 hasConceptScore W2023385492C16685009 @default.
- W2023385492 hasConceptScore W2023385492C181199279 @default.
- W2023385492 hasConceptScore W2023385492C185592680 @default.
- W2023385492 hasConceptScore W2023385492C202751555 @default.
- W2023385492 hasConceptScore W2023385492C2775838275 @default.
- W2023385492 hasConceptScore W2023385492C2776200302 @default.
- W2023385492 hasConceptScore W2023385492C2776637226 @default.
- W2023385492 hasConceptScore W2023385492C2778004101 @default.
- W2023385492 hasConceptScore W2023385492C2778248901 @default.
- W2023385492 hasConceptScore W2023385492C2778401633 @default.
- W2023385492 hasConceptScore W2023385492C2778760513 @default.
- W2023385492 hasConceptScore W2023385492C2778979269 @default.
- W2023385492 hasConceptScore W2023385492C2781057625 @default.
- W2023385492 hasConceptScore W2023385492C2992208098 @default.
- W2023385492 hasConceptScore W2023385492C538909803 @default.
- W2023385492 hasConceptScore W2023385492C55493867 @default.
- W2023385492 hasConceptScore W2023385492C71924100 @default.
- W2023385492 hasIssue "1-2" @default.
- W2023385492 hasLocation W20233854921 @default.
- W2023385492 hasLocation W20233854922 @default.
- W2023385492 hasOpenAccess W2023385492 @default.
- W2023385492 hasPrimaryLocation W20233854921 @default.
- W2023385492 hasRelatedWork W2010955122 @default.
- W2023385492 hasRelatedWork W2026610291 @default.
- W2023385492 hasRelatedWork W2036307947 @default.
- W2023385492 hasRelatedWork W2090886218 @default.
- W2023385492 hasRelatedWork W2109812645 @default.
- W2023385492 hasRelatedWork W2411394476 @default.
- W2023385492 hasRelatedWork W2411875264 @default.
- W2023385492 hasRelatedWork W2469831961 @default.
- W2023385492 hasRelatedWork W2726026000 @default.
- W2023385492 hasRelatedWork W3214998341 @default.
- W2023385492 hasVolume "8" @default.
- W2023385492 isParatext "false" @default.
- W2023385492 isRetracted "false" @default.
- W2023385492 magId "2023385492" @default.
- W2023385492 workType "article" @default.