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• W2023386736 abstract "Abstract New World primates exhibit a form of resistance to estrogens that is associated with overexpression of an estrogen response element (ERE)-binding protein (ERE-BP) and an intracellular estradiol (E2)-binding protein (IEBP). Both proteins suppress E2-mediated transcription when overexpressed in estrogen receptor-α (ERα)-positive cells. Although ERE-BP acts as a competitor for ERE occupancy by liganded ERα, the function of IEBP and its human homolog, heat-shock protein 27 (hsp27), is less clear. In data presented here, we have used E2-responsive human MCF-7 breast cancer cells to show that IEBP/hsp27 can regulate estrogen signaling as a cytosolic decoy for E2 and as a protein chaperone for ERα. Furthermore, co-immunoprecipitation, colocalization, yeast two-hybrid, and glutathione S-transferase pull-down analyses indicate that IEBP/hsp27 also interacts with ERE-BP to form a dynamic complex that appears to cycle between the cytoplasm and nucleus during normal estrogen signaling. Overexpression of either IEBP/hsp27 or ERE-BP in MCF-7 cells resulted in abnormal subcellular distribution of the IEBP/hsp27 and ERE-BP, with concomitant dysregulation of ERE occupancy as determined by chromatin immunoprecipitation. We hypothesize that IEBP/hsp27 and ERE-BP not only cause hormone resistance in New World primates but are also crucial to normal estrogen signaling in human cells. This appears to involve a physical association between the two proteins to form a complex that is able to interact with both E2 and ERα in cytosolic and nuclear compartments." @default.
• W2023386736 created "2016-06-24" @default.
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• W2023386736 date "2008-03-01" @default.
• W2023386736 modified "2023-09-27" @default.
• W2023386736 title "Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen-Binding Protein and an Estrogen Response Element-Binding Protein" @default.
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• W2023386736 doi "https://doi.org/10.1210/me.2007-0297" @default.
• W2023386736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2262167" @default.
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• W2023386736 hasPublicationYear "2008" @default.
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