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- W2023386802 abstract "Purpose To test the effects of urea, a naturally occurring benign component of serum, with ethanol when combined in order to potentially reduce the amount of ethanol needed in chemical ablation of liver tissue. Materials and Methods A 27G needle was used to inject 1 ml aliquots of urea (1-4 M) or ethanol (3-25%) solutions either alone or in combination into both in vivo and fresh ex vivo porcine liver using 100% for control. Lesions were sectioned and digital images were obtained of the fresh and formalin fixed specimens. Histology was performed on in vivo lesions. Results The appearance of the zone of coagulation ranged from dark red to pale white in both fresh and formalin fixed specimens. The lesions in the formalin fixed specimens were generally easier to visualize. Higher concentrations were noted to produce more clearly delineated coagulum. The addition of urea to low concentrations of ethanol appeared to cause an increase in coagulation. Histology of the acute in vivo specimens demonstrated cell dissociation with homogenous staining of nuclei and loss of nuclear detail. Margins of lesions showed extensive congestion and hemorrhage. Lesions with 10 and 25% ethanol alone were difficult to visualize in the fresh specimens. The lesions with 10% ethanol and 4M urea were clearly identifiable with some improvement in the visibility as the ethanol was increased to 25%. The addition of 4 molar urea made these lesions much more conspicuous, with an appearance similar to that seen with 100% ethanol. Conclusion The combination of urea and ethanol shows promise for chemical ablation with less resulting systemic toxicity and/or larger treatment volumes. Such a strategy may enable treatment of larger tumors more safely in a single session." @default.
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- W2023386802 date "2013-04-01" @default.
- W2023386802 modified "2023-09-27" @default.
- W2023386802 title "In vivo cooperative effects of urea and ethanol for chemical ablation of tissue" @default.
- W2023386802 cites W2010997003 @default.
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- W2023386802 doi "https://doi.org/10.1016/j.jvir.2013.01.331" @default.
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