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- W2023386912 abstract "We evaluated the tolerability and efficacy of M-VAC with GM-CSF in 33 patients (pts) with advanced SCCHN. All pts were males with median age (range): 47 (40–67) years and PS (WHO): 1 (0–2). All pts were chemotherapy naive and 15 pts pretreated by surgery and/or radiotherapy. Treatment: CDDP 70 mg/m 2 and DXR 30 mg/m 2 i.v. on day (D) 2, MTX 30 mg/m 2 and VLB 3 mg/m 2 i.v. on D1,15,22, GM-CSF: 5 μg/kg/D, s.c. on D3–14. Cycles (cy) were repeated every 4 weeks. 66 cy were administered, median (range): 2 (1–3). Efficacy 2 CR and 14 PR in 31 evaluable pts were observed for an overall RR of 52% (95% CI: 42–62). The duration of RC was 3 and 2 + months; 14 pts with PR were treated by radiotherapy (9 pts) or other chemotherapy (5 pts). Toxicity Anemia, neutropenia and thrombocytopenia (WHO gr ≥ 3) occurred in 3, 8 and 3 pts resp. Nausea/vomiting (WHO gr ≤ 3) were observed in 9 pts, alopecia in 20 pts and skin rash due to GM-CSF (WHO grl) in 4 pts. There were no treatment-related deaths. Conclusion M-VAC with GM-CSF had a good tolerability and efficacy in chemotherapy naive pts with advanced SCCHN." @default.
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- W2023386912 date "1995-11-01" @default.
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- W2023386912 title "438 M-VAC chemotherapy and GM-CSF in advanced, recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN)" @default.
- W2023386912 doi "https://doi.org/10.1016/0959-8049(95)95691-x" @default.
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