Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023388112> ?p ?o ?g. }
- W2023388112 endingPage "180" @default.
- W2023388112 startingPage "168" @default.
- W2023388112 abstract "The cerebral cavernous malformation (CCM) pathway is required in endothelial cells for normal cardiovascular development and to prevent postnatal vascular malformations, but its molecular effectors are not well defined. Here we show that loss of CCM signaling in endocardial cells results in mid-gestation heart failure associated with premature degradation of cardiac jelly. CCM deficiency dramatically alters endocardial and endothelial gene expression, including increased expression of the Klf2 and Klf4 transcription factors and the Adamts4 and Adamts5 proteases that degrade cardiac jelly. These changes in gene expression result from increased activity of MEKK3, a mitogen-activated protein kinase that binds CCM2 in endothelial cells. MEKK3 is both necessary and sufficient for expression of these genes, and partial loss of MEKK3 rescues cardiac defects in CCM-deficient embryos. These findings reveal a molecular mechanism by which CCM signaling controls endothelial gene expression during cardiovascular development that may also underlie CCM formation." @default.
- W2023388112 created "2016-06-24" @default.
- W2023388112 creator A5004589894 @default.
- W2023388112 creator A5009096811 @default.
- W2023388112 creator A5009327105 @default.
- W2023388112 creator A5016647349 @default.
- W2023388112 creator A5024037670 @default.
- W2023388112 creator A5031868410 @default.
- W2023388112 creator A5033126095 @default.
- W2023388112 creator A5054028527 @default.
- W2023388112 creator A5073917775 @default.
- W2023388112 creator A5077457004 @default.
- W2023388112 creator A5079402797 @default.
- W2023388112 creator A5079797111 @default.
- W2023388112 creator A5080273967 @default.
- W2023388112 creator A5083376044 @default.
- W2023388112 creator A5089177966 @default.
- W2023388112 date "2015-01-01" @default.
- W2023388112 modified "2023-10-14" @default.
- W2023388112 title "The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression" @default.
- W2023388112 cites W1499561015 @default.
- W2023388112 cites W1583045777 @default.
- W2023388112 cites W1896836582 @default.
- W2023388112 cites W1963876426 @default.
- W2023388112 cites W1967683406 @default.
- W2023388112 cites W1975646272 @default.
- W2023388112 cites W1975676532 @default.
- W2023388112 cites W1979600880 @default.
- W2023388112 cites W1982012141 @default.
- W2023388112 cites W1986774614 @default.
- W2023388112 cites W1993928278 @default.
- W2023388112 cites W1994085715 @default.
- W2023388112 cites W1995869857 @default.
- W2023388112 cites W2002455222 @default.
- W2023388112 cites W2002970726 @default.
- W2023388112 cites W2003401611 @default.
- W2023388112 cites W2005517764 @default.
- W2023388112 cites W2012399826 @default.
- W2023388112 cites W2016010426 @default.
- W2023388112 cites W2021648619 @default.
- W2023388112 cites W2021730851 @default.
- W2023388112 cites W2025198517 @default.
- W2023388112 cites W2025645553 @default.
- W2023388112 cites W2025692282 @default.
- W2023388112 cites W2027000467 @default.
- W2023388112 cites W2027052842 @default.
- W2023388112 cites W2028017696 @default.
- W2023388112 cites W2029030025 @default.
- W2023388112 cites W2032392598 @default.
- W2023388112 cites W2039294916 @default.
- W2023388112 cites W2046464403 @default.
- W2023388112 cites W2056026409 @default.
- W2023388112 cites W2058599028 @default.
- W2023388112 cites W2059519946 @default.
- W2023388112 cites W2066287407 @default.
- W2023388112 cites W2068440074 @default.
- W2023388112 cites W2073187339 @default.
- W2023388112 cites W2073235331 @default.
- W2023388112 cites W2074214268 @default.
- W2023388112 cites W2088320964 @default.
- W2023388112 cites W2094722906 @default.
- W2023388112 cites W2095035711 @default.
- W2023388112 cites W2099043491 @default.
- W2023388112 cites W2105707485 @default.
- W2023388112 cites W2107798346 @default.
- W2023388112 cites W2112485268 @default.
- W2023388112 cites W2115636228 @default.
- W2023388112 cites W2121535505 @default.
- W2023388112 cites W2128232666 @default.
- W2023388112 cites W2128316931 @default.
- W2023388112 cites W2128466784 @default.
- W2023388112 cites W2130856505 @default.
- W2023388112 cites W2133546870 @default.
- W2023388112 cites W2142694254 @default.
- W2023388112 cites W2146234609 @default.
- W2023388112 cites W2147107152 @default.
- W2023388112 cites W2147327763 @default.
- W2023388112 cites W2147892517 @default.
- W2023388112 cites W2169001927 @default.
- W2023388112 cites W2169030822 @default.
- W2023388112 cites W2171538469 @default.
- W2023388112 cites W2427995099 @default.
- W2023388112 doi "https://doi.org/10.1016/j.devcel.2014.12.009" @default.
- W2023388112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4589864" @default.
- W2023388112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25625206" @default.
- W2023388112 hasPublicationYear "2015" @default.
- W2023388112 type Work @default.
- W2023388112 sameAs 2023388112 @default.
- W2023388112 citedByCount "126" @default.
- W2023388112 countsByYear W20233881122015 @default.
- W2023388112 countsByYear W20233881122016 @default.
- W2023388112 countsByYear W20233881122017 @default.
- W2023388112 countsByYear W20233881122018 @default.
- W2023388112 countsByYear W20233881122019 @default.
- W2023388112 countsByYear W20233881122020 @default.
- W2023388112 countsByYear W20233881122021 @default.
- W2023388112 countsByYear W20233881122022 @default.
- W2023388112 countsByYear W20233881122023 @default.