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• W2023388424 startingPage "10553" @default.
• W2023388424 abstract "RIG-I has been implicated in innate immunity by sensing intracellular viral RNAs and inducing type I IFN production. However, we have found a significant RIG-I induction in a biological setting without active viral infection-namely, during RA-induced terminal granulocytic differentiation of acute myeloid leukemias. Here, we present evidence that a significant Rig-I induction also occurs during normal myelopoiesis and that the disruption of the Rig-I gene in mice leads to the development of a progressive myeloproliferative disorder. The initiation of progressive myeloproliferative disorder is mainly due to an intrinsic defect of Rig-I(-/-) myeloid cells, which are characterized by a reduced expression of IFN consensus sequence binding protein, a major regulator of myeloid differentiation. Thus, our study reveals a critical regulatory role of Rig-I in modulating the generation and differentiation of granulocytes." @default.
• W2023388424 created "2016-06-24" @default.
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• W2023388424 date "2008-07-29" @default.
• W2023388424 modified "2023-10-14" @default.
• W2023388424 title "RIG-I plays a critical role in negatively regulating granulocytic proliferation" @default.
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• W2023388424 doi "https://doi.org/10.1073/pnas.0804895105" @default.
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