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- W2023389405 abstract "Lipoplexes containing a hyaluronic acid−dioleoylphosphatidylethanolamine (HA−DOPE) conjugate were designed to target the CD44 receptor on breast cancer cells. Cationic liposomes composed of a mixture of [2-(2,3-didodecyloxypropyl)hydroxyethyl]ammonium bromide (DE) and dioleoylphosphatidylethanolamine (DOPE) with or without HA−DOPE were prepared, characterized, and used to form a complex with plasmid DNA pCMV-luc. Lipoplexes displayed a negative zeta potential and a mean diameter between 250−300 nm. Cytotoxicity and transfection efficiency of the lipoplexes were determined on the MDA-MB-231and MCF-7 breast cancer cell lines. Cytotoxicity was not modified by the presence of HA−DOPE. However HA−DOPE increased the level of transfection on CD44-expressing MDA-MB-231 cells compared to the MCF-7 line, which expresses very low levels of CD44. The transfection on the MDA-MB-231 cells was highly inhibited by anti-CD44 Hermes-1 antibody but not by the nonspecific anti-ErbB2 antibody. In conclusion, cationic liposomes containing the HA−DOPE conjugate mediated good transfection on CD44 expressing cell lines in culture." @default.
- W2023389405 created "2016-06-24" @default.
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- W2023389405 date "2009-05-26" @default.
- W2023389405 modified "2023-09-30" @default.
- W2023389405 title "Lipoplexes Targeting the CD44 Hyaluronic Acid Receptor for Efficient Transfection of Breast Cancer Cells" @default.
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- W2023389405 doi "https://doi.org/10.1021/mp800215d" @default.
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