FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023390812> ?p ?o ?g. }

• W2023390812 endingPage "471" @default.
• W2023390812 startingPage "465" @default.
• W2023390812 abstract "High levels of small, dense LDL in plasma are associated with increased risk for cardiovascular disease. There are some biochemical characteristics that may render small, dense LDL particles more atherogenic than larger, buoyant LDL particles. First, small, dense LDL particles contain less phospholipids and unesterified cholesterol in their surface monolayer than do large, buoyant LDL particles. This difference in lipid content appears to induce changes in the conformation of apolipoprotein B-100, leading to more exposure of proteoglycan-binding regions. This may be one reason for the high-affinity binding of small, dense LDL to arterial proteoglycans. Reduction of the phospholipid content in the surface monolayer LDL by treatment with secretory phospholipase A2 (sPLA2) forms small, dense LDL with an enhanced tendency to interact with proteoglycans. Circulating levels of sPLA2-IIA appears to be an independent risk factor for coronary artery disease and a predictor of cardiovascular events. In addition, in-vivo studies support the hypothesis that sPLA2 proteins contribute to atherogenesis and its clinical consequences. These data suggest that modification of LDL by sPLA2 in the arterial tissue or in plasma may be a mechanism for the generation of atherogenic lipoprotein particles in vivo, with a high tendency to be entrapped in the arterial extracellular matrix." @default.
• W2023390812 created "2016-06-24" @default.
• W2023390812 creator A5037748733 @default.
• W2023390812 creator A5047447621 @default.
• W2023390812 creator A5058639659 @default.
• W2023390812 date "2000-10-01" @default.
• W2023390812 modified "2023-10-01" @default.
• W2023390812 title "Phospholipase A2 and small, dense low-density lipoprotein" @default.
• W2023390812 cites W1573258040 @default.
• W2023390812 cites W1585634514 @default.
• W2023390812 cites W1659985814 @default.
• W2023390812 cites W1869308072 @default.
• W2023390812 cites W1891823817 @default.
• W2023390812 cites W1937455559 @default.
• W2023390812 cites W1939640254 @default.
• W2023390812 cites W1964767384 @default.
• W2023390812 cites W1967286067 @default.
• W2023390812 cites W1967735008 @default.
• W2023390812 cites W1970898912 @default.
• W2023390812 cites W1990778395 @default.
• W2023390812 cites W1995617096 @default.
• W2023390812 cites W1996460539 @default.
• W2023390812 cites W1998949162 @default.
• W2023390812 cites W1999551921 @default.
• W2023390812 cites W2013720728 @default.
• W2023390812 cites W2025029890 @default.
• W2023390812 cites W2025382042 @default.
• W2023390812 cites W2028872016 @default.
• W2023390812 cites W2033589357 @default.
• W2023390812 cites W2035446379 @default.
• W2023390812 cites W2037614650 @default.
• W2023390812 cites W2040827725 @default.
• W2023390812 cites W2041003777 @default.
• W2023390812 cites W2045600823 @default.
• W2023390812 cites W2048081925 @default.
• W2023390812 cites W2050758709 @default.
• W2023390812 cites W205176221 @default.
• W2023390812 cites W2053166689 @default.
• W2023390812 cites W2054133244 @default.
• W2023390812 cites W2058130388 @default.
• W2023390812 cites W2073000116 @default.
• W2023390812 cites W2073190601 @default.
• W2023390812 cites W2077065351 @default.
• W2023390812 cites W2078679613 @default.
• W2023390812 cites W2080094627 @default.
• W2023390812 cites W2080550444 @default.
• W2023390812 cites W2084116516 @default.
• W2023390812 cites W2084468357 @default.
• W2023390812 cites W2097208635 @default.
• W2023390812 cites W2103342908 @default.
• W2023390812 cites W2112965137 @default.
• W2023390812 cites W2117950105 @default.
• W2023390812 cites W2122167768 @default.
• W2023390812 cites W2122865563 @default.
• W2023390812 cites W2128222537 @default.
• W2023390812 cites W2129595368 @default.
• W2023390812 cites W2135325639 @default.
• W2023390812 cites W2146322658 @default.
• W2023390812 cites W2152188478 @default.
• W2023390812 cites W2153860720 @default.
• W2023390812 cites W2157598033 @default.
• W2023390812 cites W2161672362 @default.
• W2023390812 cites W2165334001 @default.
• W2023390812 cites W2165669186 @default.
• W2023390812 cites W2166667806 @default.
• W2023390812 cites W2166689622 @default.
• W2023390812 cites W2170582496 @default.
• W2023390812 cites W2170583921 @default.
• W2023390812 cites W2183707031 @default.
• W2023390812 cites W2306437724 @default.
• W2023390812 cites W2324841714 @default.
• W2023390812 cites W2473455258 @default.
• W2023390812 cites W3014882782 @default.
• W2023390812 doi "https://doi.org/10.1097/00041433-200010000-00004" @default.
• W2023390812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11048889" @default.
• W2023390812 hasPublicationYear "2000" @default.
• W2023390812 type Work @default.
• W2023390812 sameAs 2023390812 @default.
• W2023390812 citedByCount "89" @default.
• W2023390812 countsByYear W20233908122012 @default.
• W2023390812 countsByYear W20233908122013 @default.
• W2023390812 countsByYear W20233908122014 @default.
• W2023390812 countsByYear W20233908122015 @default.
• W2023390812 countsByYear W20233908122017 @default.
• W2023390812 countsByYear W20233908122020 @default.
• W2023390812 countsByYear W20233908122021 @default.
• W2023390812 countsByYear W20233908122022 @default.
• W2023390812 countsByYear W20233908122023 @default.
• W2023390812 crossrefType "journal-article" @default.
• W2023390812 hasAuthorship W2023390812A5037748733 @default.
• W2023390812 hasAuthorship W2023390812A5047447621 @default.
• W2023390812 hasAuthorship W2023390812A5058639659 @default.
• W2023390812 hasConcept C12554922 @default.
• W2023390812 hasConcept C126322002 @default.
• W2023390812 hasConcept C12927208 @default.
• W2023390812 hasConcept C134018914 @default.
• W2023390812 hasConcept C150903083 @default.
• W2023390812 hasConcept C181199279 @default.

• next