Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023391013> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2023391013 abstract "The Human Ether-a-go-go Related Gene (hERG) encodes a voltage-activated K+ channel. hERG contributes to the repolarization of the ventricular action potential as the primary component of the cardiac delayed rectifier K+ current (IKr) and has also been shown by many groups to modulate neuronal firing frequency. Disruption of channel function by inherited mutations in the gene encoding hERG has been shown to cause type 2 long QT syndrome (LQT2). hERG gating is characterized by rapid inactivation upon depolarization and rapid recovery from inactivation and slow closing (deactivation) upon repolarization. Unlike other K+ channels, hERG, ELK and EAG channels contain an N-terminal eag domain, composed of a PAS domain and a PAS-Cap domain in the N-terminal region. Inter-subunit interactions between the N-terminal eag domain and the C-terminal cyclic-nucleotide binding homology domain regulate slow deactivation kinetics in the original variant of hERG, hERG1a channels. A recently discovered splice variant, hERG 1a-3.1, has much faster deactivation and has been linked to schizophrenia. We demonstrate in HEK293 cells, that co-expression of hERG1a-3.1 with soluble eag domain peptide partially rescues deactivation kinetics, presumably by providing a fully functional eag domain to the eag-truncated hERG1a-3.1 to slow channel deactivation. Cells co-expressing hERG1a-3.1 + eag domain polypeptides had significantly slower fast and slow time constants of deactivation compared to hERG1a-3.1 channels alone (p<0.05). We conclude that eag domain polypeptides are able to partially restore deactivation gating. Current experiments are utilizing FRET to assess if the hERG1a-3.1 C-terminus interaction with the eag domain is physically disrupted." @default.
- W2023391013 created "2016-06-24" @default.
- W2023391013 creator A5004583814 @default.
- W2023391013 creator A5069062816 @default.
- W2023391013 date "2015-01-01" @default.
- W2023391013 modified "2023-10-17" @default.
- W2023391013 title "An Eag Domain Polypeptide Regulates the Deactivation Kinetics of the hERG 1A-3.1 Splice Variant Linked to Schizophrenia" @default.
- W2023391013 doi "https://doi.org/10.1016/j.bpj.2014.11.1516" @default.
- W2023391013 hasPublicationYear "2015" @default.
- W2023391013 type Work @default.
- W2023391013 sameAs 2023391013 @default.
- W2023391013 citedByCount "0" @default.
- W2023391013 crossrefType "journal-article" @default.
- W2023391013 hasAuthorship W2023391013A5004583814 @default.
- W2023391013 hasAuthorship W2023391013A5069062816 @default.
- W2023391013 hasBestOaLocation W20233910131 @default.
- W2023391013 hasConcept C104317684 @default.
- W2023391013 hasConcept C118441451 @default.
- W2023391013 hasConcept C12554922 @default.
- W2023391013 hasConcept C126322002 @default.
- W2023391013 hasConcept C146403970 @default.
- W2023391013 hasConcept C169760540 @default.
- W2023391013 hasConcept C174510640 @default.
- W2023391013 hasConcept C185263204 @default.
- W2023391013 hasConcept C185592680 @default.
- W2023391013 hasConcept C194544171 @default.
- W2023391013 hasConcept C2778875234 @default.
- W2023391013 hasConcept C2779362680 @default.
- W2023391013 hasConcept C2779703243 @default.
- W2023391013 hasConcept C55493867 @default.
- W2023391013 hasConcept C71924100 @default.
- W2023391013 hasConcept C79743260 @default.
- W2023391013 hasConcept C83743174 @default.
- W2023391013 hasConcept C86339819 @default.
- W2023391013 hasConcept C86803240 @default.
- W2023391013 hasConcept C95444343 @default.
- W2023391013 hasConceptScore W2023391013C104317684 @default.
- W2023391013 hasConceptScore W2023391013C118441451 @default.
- W2023391013 hasConceptScore W2023391013C12554922 @default.
- W2023391013 hasConceptScore W2023391013C126322002 @default.
- W2023391013 hasConceptScore W2023391013C146403970 @default.
- W2023391013 hasConceptScore W2023391013C169760540 @default.
- W2023391013 hasConceptScore W2023391013C174510640 @default.
- W2023391013 hasConceptScore W2023391013C185263204 @default.
- W2023391013 hasConceptScore W2023391013C185592680 @default.
- W2023391013 hasConceptScore W2023391013C194544171 @default.
- W2023391013 hasConceptScore W2023391013C2778875234 @default.
- W2023391013 hasConceptScore W2023391013C2779362680 @default.
- W2023391013 hasConceptScore W2023391013C2779703243 @default.
- W2023391013 hasConceptScore W2023391013C55493867 @default.
- W2023391013 hasConceptScore W2023391013C71924100 @default.
- W2023391013 hasConceptScore W2023391013C79743260 @default.
- W2023391013 hasConceptScore W2023391013C83743174 @default.
- W2023391013 hasConceptScore W2023391013C86339819 @default.
- W2023391013 hasConceptScore W2023391013C86803240 @default.
- W2023391013 hasConceptScore W2023391013C95444343 @default.
- W2023391013 hasLocation W20233910131 @default.
- W2023391013 hasOpenAccess W2023391013 @default.
- W2023391013 hasPrimaryLocation W20233910131 @default.
- W2023391013 hasRelatedWork W1602039171 @default.
- W2023391013 hasRelatedWork W1768502166 @default.
- W2023391013 hasRelatedWork W1971993744 @default.
- W2023391013 hasRelatedWork W1984574473 @default.
- W2023391013 hasRelatedWork W2000319252 @default.
- W2023391013 hasRelatedWork W2009902631 @default.
- W2023391013 hasRelatedWork W2030885752 @default.
- W2023391013 hasRelatedWork W2041033033 @default.
- W2023391013 hasRelatedWork W2041596890 @default.
- W2023391013 hasRelatedWork W2051771991 @default.
- W2023391013 hasRelatedWork W2055522494 @default.
- W2023391013 hasRelatedWork W2077885954 @default.
- W2023391013 hasRelatedWork W2087666227 @default.
- W2023391013 hasRelatedWork W2113384057 @default.
- W2023391013 hasRelatedWork W2113886065 @default.
- W2023391013 hasRelatedWork W2120642212 @default.
- W2023391013 hasRelatedWork W2153108946 @default.
- W2023391013 hasRelatedWork W2900547464 @default.
- W2023391013 hasRelatedWork W2916097017 @default.
- W2023391013 hasRelatedWork W3045618311 @default.
- W2023391013 isParatext "false" @default.
- W2023391013 isRetracted "false" @default.
- W2023391013 magId "2023391013" @default.
- W2023391013 workType "article" @default.