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• W2023391041 abstract "Interleukin-1β (IL-1β), a key-cytokine in osteoarthritis, impairs TGFβ signaling through TβRII down-regulation by increasing its degradation. Here, we investigated the molecular mechanism that controls TßRII fate in IL-1ß treated cells. Chondrocytes were treated with IL-1ß in the presence of different inhibitors. TßRII and Cav-1 expression were assayed by Western blot and RT-PCR. We showed that IL-1ß-induced degradation of TßRII is dependent on proteasome and on its internalization in caveolae. In addition, IL-1ß enhances Cav-1 expression, a major constituent of lipid raft. In conclusion, we enlighten a new mechanism by which IL-1ß antagonizes TGFß pathway and propose a model of TßRII turnover regulation upon IL-1ß treatment." @default.
• W2023391041 created "2016-06-24" @default.
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• W2023391041 date "2012-05-01" @default.
• W2023391041 modified "2023-10-16" @default.
• W2023391041 title "Regulatory mechanism of transforming growth factor beta receptor type II degradation by interleukin-1 in primary chondrocytes" @default.
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• W2023391041 doi "https://doi.org/10.1016/j.bbamcr.2012.02.017" @default.
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