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- W2023391282 abstract "In the central amygdala (CeA), ethanol acts via corticotrophin-releasing factor (CRF) type 1 receptors to enhance GABA release. Amygdala CRF mediates anxiety associated with stress and drug dependence, and it regulates ethanol intake. Because mutant mice that lack PKCε exhibit reduced anxiety-like behavior and alcohol consumption, we investigated whether PKCε lies downstream of CRF 1 receptors in the CeA. Compared with PKCε +/+ CeA neurons, PKCε −/− neurons showed increased GABAergic tone due to enhanced GABA release. CRF and ethanol stimulated GABA release in the PKCε +/+ CeA, but not in the PKCε −/− CeA. A PKCε-specific inhibitor blocked both CRF- and ethanol-induced GABA release in the PKCε +/+ CeA, confirming findings in the PKCε −/− CeA. These results identify a PKCε signaling pathway in the CeA that is activated by CRF 1 receptor stimulation, mediates GABA release at nerve terminals, and regulates anxiety and alcohol consumption." @default.
- W2023391282 created "2016-06-24" @default.
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- W2023391282 date "2008-06-17" @default.
- W2023391282 modified "2023-10-11" @default.
- W2023391282 title "Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala" @default.
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- W2023391282 doi "https://doi.org/10.1073/pnas.0802302105" @default.
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