Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023392368> ?p ?o ?g. }
- W2023392368 endingPage "1390" @default.
- W2023392368 startingPage "1384" @default.
- W2023392368 abstract "Plasmin system components are upregulated after partial hepatectomy, but their contribution to surgery-induced hepatic angiogenesis and regeneration is unclear. Liver regeneration and angiogenesis after partial hepatectomy were examined in mice lacking plasminogen or urokinase plasminogen activator (uPA).Mice with a single-gene deletion of plasminogen or uPA were subjected to 70 per cent partial hepatectomy. Liver regeneration was measured as relative liver weight and cell proliferation index. Angiogenesis was quantified by determining hepatic microvessel density after staining for sinusoidal endothelial cells.The liver remnant weight was significantly reduced in mice lacking plasminogen or uPA compared with that in wild-type mice on days 2 and 7 after partial hepatectomy. This correlated with impaired cell proliferation. In wild-type mice, regeneration was accompanied by a significant increase in microvessel density after hepatectomy; this increase was impaired in plasminogen-deficient mice.Plasminogen and uPA are essential for optimal liver regeneration. In addition, plasminogen appears to be a major determinant in regeneration-associated hepatic angiogenesis." @default.
- W2023392368 created "2016-06-24" @default.
- W2023392368 creator A5047152113 @default.
- W2023392368 creator A5047885970 @default.
- W2023392368 creator A5060207753 @default.
- W2023392368 creator A5068038653 @default.
- W2023392368 creator A5071570709 @default.
- W2023392368 creator A5071741692 @default.
- W2023392368 date "2003-10-03" @default.
- W2023392368 modified "2023-10-12" @default.
- W2023392368 title "Plasminogen mediates liver regeneration and angiogenesis after experimental partial hepatectomy" @default.
- W2023392368 cites W1470345216 @default.
- W2023392368 cites W1786861597 @default.
- W2023392368 cites W1966571134 @default.
- W2023392368 cites W1976753068 @default.
- W2023392368 cites W1980622891 @default.
- W2023392368 cites W2010501735 @default.
- W2023392368 cites W2016918804 @default.
- W2023392368 cites W2027588009 @default.
- W2023392368 cites W2033206863 @default.
- W2023392368 cites W2034776372 @default.
- W2023392368 cites W2040552696 @default.
- W2023392368 cites W2044902540 @default.
- W2023392368 cites W2050483870 @default.
- W2023392368 cites W2057093021 @default.
- W2023392368 cites W2073129561 @default.
- W2023392368 cites W2081589114 @default.
- W2023392368 cites W2085804760 @default.
- W2023392368 cites W2101356447 @default.
- W2023392368 cites W2119076869 @default.
- W2023392368 cites W2133049684 @default.
- W2023392368 cites W2137086343 @default.
- W2023392368 cites W2144264908 @default.
- W2023392368 cites W2146421436 @default.
- W2023392368 cites W2159362195 @default.
- W2023392368 cites W23122061 @default.
- W2023392368 cites W2319962899 @default.
- W2023392368 cites W2397513198 @default.
- W2023392368 cites W2418037826 @default.
- W2023392368 cites W4211173486 @default.
- W2023392368 cites W4237329722 @default.
- W2023392368 doi "https://doi.org/10.1002/bjs.4275" @default.
- W2023392368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14598419" @default.
- W2023392368 hasPublicationYear "2003" @default.
- W2023392368 type Work @default.
- W2023392368 sameAs 2023392368 @default.
- W2023392368 citedByCount "33" @default.
- W2023392368 countsByYear W20233923682012 @default.
- W2023392368 countsByYear W20233923682013 @default.
- W2023392368 countsByYear W20233923682014 @default.
- W2023392368 countsByYear W20233923682015 @default.
- W2023392368 countsByYear W20233923682016 @default.
- W2023392368 countsByYear W20233923682018 @default.
- W2023392368 countsByYear W20233923682019 @default.
- W2023392368 countsByYear W20233923682020 @default.
- W2023392368 countsByYear W20233923682021 @default.
- W2023392368 countsByYear W20233923682022 @default.
- W2023392368 crossrefType "journal-article" @default.
- W2023392368 hasAuthorship W2023392368A5047152113 @default.
- W2023392368 hasAuthorship W2023392368A5047885970 @default.
- W2023392368 hasAuthorship W2023392368A5060207753 @default.
- W2023392368 hasAuthorship W2023392368A5068038653 @default.
- W2023392368 hasAuthorship W2023392368A5071570709 @default.
- W2023392368 hasAuthorship W2023392368A5071741692 @default.
- W2023392368 hasBestOaLocation W20233923681 @default.
- W2023392368 hasConcept C126322002 @default.
- W2023392368 hasConcept C134018914 @default.
- W2023392368 hasConcept C141071460 @default.
- W2023392368 hasConcept C142724271 @default.
- W2023392368 hasConcept C159110652 @default.
- W2023392368 hasConcept C171056886 @default.
- W2023392368 hasConcept C2776436680 @default.
- W2023392368 hasConcept C2776795407 @default.
- W2023392368 hasConcept C2776909242 @default.
- W2023392368 hasConcept C2778271429 @default.
- W2023392368 hasConcept C2779679481 @default.
- W2023392368 hasConcept C2780394083 @default.
- W2023392368 hasConcept C71924100 @default.
- W2023392368 hasConcept C86803240 @default.
- W2023392368 hasConcept C95444343 @default.
- W2023392368 hasConceptScore W2023392368C126322002 @default.
- W2023392368 hasConceptScore W2023392368C134018914 @default.
- W2023392368 hasConceptScore W2023392368C141071460 @default.
- W2023392368 hasConceptScore W2023392368C142724271 @default.
- W2023392368 hasConceptScore W2023392368C159110652 @default.
- W2023392368 hasConceptScore W2023392368C171056886 @default.
- W2023392368 hasConceptScore W2023392368C2776436680 @default.
- W2023392368 hasConceptScore W2023392368C2776795407 @default.
- W2023392368 hasConceptScore W2023392368C2776909242 @default.
- W2023392368 hasConceptScore W2023392368C2778271429 @default.
- W2023392368 hasConceptScore W2023392368C2779679481 @default.
- W2023392368 hasConceptScore W2023392368C2780394083 @default.
- W2023392368 hasConceptScore W2023392368C71924100 @default.
- W2023392368 hasConceptScore W2023392368C86803240 @default.
- W2023392368 hasConceptScore W2023392368C95444343 @default.
- W2023392368 hasIssue "11" @default.
- W2023392368 hasLocation W20233923681 @default.
- W2023392368 hasLocation W20233923682 @default.