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- W2023392523 abstract "The effects of cooling, anoxia, cocaine, atropine and dibenamine on the actions of cholinesters and alkyltrimethylammoniums were tested on the rat isolated small intestine. The response of the rat small intestine to partial agonists such as BuCH, HeTMA and EtTMA were considerably reduced by cooling, anoxia and cocaine, although the responses to pure agonists were unaffected by the same treatment. In the experiments at 13°C the partial agonists caused a parallel displacement of the dose-response curve of ACh towards higher concentrations, indicating an atropine-like action. These results suggest that the partial agonist contracts the small intestine by the liberation of ACh, and at the same time antagonizes the action of the released ACh at the ACh receptor. The fraction of free receptors after incubation with dibenamine and the efficacies of the pure agonists which were calculated by the method of Furchgott are in good agreement with each other, which suggests that the strength of stimulus induced by the agonist-receptor complexes of the pure agonists is identical." @default.
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- W2023392523 date "1968-04-01" @default.
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- W2023392523 title "An analysis of the sites of action of some partial agonists" @default.
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- W2023392523 doi "https://doi.org/10.1016/0014-2999(68)90048-4" @default.
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