Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023392666> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2023392666 endingPage "65" @default.
- W2023392666 startingPage "55" @default.
- W2023392666 abstract "High doses of dl-amphetamine (15-40 mg/kg in free base, s.c.) inhibited the cell proliferation in the forebrain of 10-day-old rats 2 h after treatment, in terms of the incorporation of [3H]-thymidine into DNA. The relative specific radioactivity of DNA was decreased to 70% compared to controls. The norepinephrine level of the forebrain was reduced to 30-50% of the control value. The observed elevation of plasma corticosterone level did not appear to mediate the effect on cell proliferation. Kinetic studies indicated that the entry of precursor from the blood to the brain tissue was enhanced, but the higher tissue concentration of precursor was not utilized in the DNA synthesis with the same speed. The phosphorylation of radioactive thymidine to thymidine phosphates was only slightly inhibited, and the suppression of DNA synthesis was evident even after the correction made on the basis of concentration of radioactivity thymidine phosphates available for synthesis. DNA synthesis in the cerebellum was not suppressed by amphetamine treatment. The possible connection between the change in norepinephrine pools and the proliferative activity is considered." @default.
- W2023392666 created "2016-06-24" @default.
- W2023392666 creator A5025100932 @default.
- W2023392666 creator A5026178486 @default.
- W2023392666 date "1981-01-01" @default.
- W2023392666 modified "2023-09-27" @default.
- W2023392666 title "Effect of Amphetamine on the Metabolism and Incorporation of [<sup>3</sup>H]-Thymidine into DNA of Developing Rat Brain" @default.
- W2023392666 doi "https://doi.org/10.1159/000112741" @default.
- W2023392666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7215205" @default.
- W2023392666 hasPublicationYear "1981" @default.
- W2023392666 type Work @default.
- W2023392666 sameAs 2023392666 @default.
- W2023392666 citedByCount "7" @default.
- W2023392666 crossrefType "journal-article" @default.
- W2023392666 hasAuthorship W2023392666A5025100932 @default.
- W2023392666 hasAuthorship W2023392666A5026178486 @default.
- W2023392666 hasConcept C126322002 @default.
- W2023392666 hasConcept C134018914 @default.
- W2023392666 hasConcept C185592680 @default.
- W2023392666 hasConcept C2777108182 @default.
- W2023392666 hasConcept C2777193897 @default.
- W2023392666 hasConcept C2778514916 @default.
- W2023392666 hasConcept C2779652256 @default.
- W2023392666 hasConcept C2779715522 @default.
- W2023392666 hasConcept C513476851 @default.
- W2023392666 hasConcept C529278444 @default.
- W2023392666 hasConcept C552990157 @default.
- W2023392666 hasConcept C55493867 @default.
- W2023392666 hasConcept C62112901 @default.
- W2023392666 hasConcept C62231903 @default.
- W2023392666 hasConcept C64241487 @default.
- W2023392666 hasConcept C71924100 @default.
- W2023392666 hasConcept C86803240 @default.
- W2023392666 hasConceptScore W2023392666C126322002 @default.
- W2023392666 hasConceptScore W2023392666C134018914 @default.
- W2023392666 hasConceptScore W2023392666C185592680 @default.
- W2023392666 hasConceptScore W2023392666C2777108182 @default.
- W2023392666 hasConceptScore W2023392666C2777193897 @default.
- W2023392666 hasConceptScore W2023392666C2778514916 @default.
- W2023392666 hasConceptScore W2023392666C2779652256 @default.
- W2023392666 hasConceptScore W2023392666C2779715522 @default.
- W2023392666 hasConceptScore W2023392666C513476851 @default.
- W2023392666 hasConceptScore W2023392666C529278444 @default.
- W2023392666 hasConceptScore W2023392666C552990157 @default.
- W2023392666 hasConceptScore W2023392666C55493867 @default.
- W2023392666 hasConceptScore W2023392666C62112901 @default.
- W2023392666 hasConceptScore W2023392666C62231903 @default.
- W2023392666 hasConceptScore W2023392666C64241487 @default.
- W2023392666 hasConceptScore W2023392666C71924100 @default.
- W2023392666 hasConceptScore W2023392666C86803240 @default.
- W2023392666 hasIssue "1" @default.
- W2023392666 hasLocation W20233926661 @default.
- W2023392666 hasLocation W20233926662 @default.
- W2023392666 hasOpenAccess W2023392666 @default.
- W2023392666 hasPrimaryLocation W20233926661 @default.
- W2023392666 hasRelatedWork W1997662870 @default.
- W2023392666 hasRelatedWork W2004693055 @default.
- W2023392666 hasRelatedWork W2007920416 @default.
- W2023392666 hasRelatedWork W2012949231 @default.
- W2023392666 hasRelatedWork W2023392666 @default.
- W2023392666 hasRelatedWork W2036839415 @default.
- W2023392666 hasRelatedWork W2046544233 @default.
- W2023392666 hasRelatedWork W2077107952 @default.
- W2023392666 hasRelatedWork W2089103608 @default.
- W2023392666 hasRelatedWork W3021984386 @default.
- W2023392666 hasVolume "4" @default.
- W2023392666 isParatext "false" @default.
- W2023392666 isRetracted "false" @default.
- W2023392666 magId "2023392666" @default.
- W2023392666 workType "article" @default.