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- W2023393975 endingPage "185" @default.
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- W2023393975 abstract "A characteristic feature of malignant glial tumors (gliomas) is their tendency to diffusely infiltrate the nervous system preventing their complete surgical resection. Proteases play a decisive role in this malignant process, either by degradation of brain extracellular matrix (ECM) components, adhesion molecules, or by regulating the activity of growth and chemotactic factors. Secreted matrix metalloproteinases (MMPs) and ADAMTS proteases (ADAMs with thrombospondin motifs) cleave different ECM components like the proteoglycans (lecticans) aggrecan, versican, neurocan and brevican with selective preferences; they are further regulated by endogenous inhibitors and activating metallo- and serine proteases. Cell surface proteases of the ADAM family (A Disintegrin And Metalloproteinase), but also serine proteases regulate the activity of growth factors and chemokines that act as autocrine / paracrine stimulators within gliomas. Thus, proteases play a decisive role for the spread and growth of gliomas and are prominent targets for their therapy." @default.
- W2023393975 created "2016-06-24" @default.
- W2023393975 creator A5009550643 @default.
- W2023393975 creator A5042386193 @default.
- W2023393975 creator A5063858179 @default.
- W2023393975 date "2012-04-01" @default.
- W2023393975 modified "2023-10-16" @default.
- W2023393975 title "Lost in disruption: Role of proteases in glioma invasion and progression" @default.
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- W2023393975 doi "https://doi.org/10.1016/j.bbcan.2011.12.001" @default.
- W2023393975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22209868" @default.
- W2023393975 hasPublicationYear "2012" @default.