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- W2023394436 abstract "To the Editor. We read the recent article by Valaes et al1 on the control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase (G-6-PD)-deficient neonates by the use of Sn-mesoporphyrin (SnMP) with great interest. However, we were concerned that, in the absence of a simultaneous control group, and lack of identical criteria for the institution of phototherapy between the 1996 study group and the 1994 historical controls, the conclusion that SnMP supplanted the need for phototherapy to control hyperbilirubinemia is unfounded.Neonates who were randomized to the therapeutic study group in 1996 received the SnMP at the identical level of serum bilirubin that “control” neonates would have commenced phototherapy at the Metera Maternity Hospital in 1994, or even in 1996, had they not been part of this study. Therefore, at this stage, by definition, the “controls” for the therapeutic wing of the trial were all receiving phototherapy. The therapeutic group did not receive supplementary phototherapy at the same level as was in force in 1994, but at a new, higher level of serum bilirubin, chosen arbitrarily for the purpose of the study. The fact that none of the SnMP treated neonates reached this new cut-off point cannot be …" @default.
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- W2023394436 date "1999-02-01" @default.
- W2023394436 modified "2023-09-26" @default.
- W2023394436 title "Control of Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-Deficient Newborns" @default.
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- W2023394436 doi "https://doi.org/10.1542/peds.103.2.536" @default.
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