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- W2023394669 abstract "Hydrogen sulfide (H 2 S) influences many aspects of an inflammatory response, and can exert potent cytoprotective actions. When a tissue is injured, H 2 S promotes repair of the tissue and resolution of the associated inflammation. Because of these actions, H 2 S is an attractive candidate molecule to be exploited in the design of safer and more effective anti-inflammatory drugs. For example, among the most commonly used drugs are the nonsteroidal anti-inflammatory drugs (NSAIDs) that are the first-line therapy for many disorders, including osteoarthritis. These drugs are effective at reducing pain and inflammation, but carry a high risk of serious adverse effects, particularly gastrointestinal (GI) ulceration and bleeding. H 2 S-releasing NSAIDs show dramatically improved GI safety and equivalent or better anti-inflammatory efficacy as compared to conventional NSAIDs. This GI safety is observed when the drugs are tested in animal models mimicking the co-morbidities in humans that are associated with increased susceptibility to GI ulceration, including hypertension, diabetes, obesity and old age. Currently available medications aimed at preventing the GI ulceration caused by NSAIDs are not effective in reducing small intestinal injury. In contrast, the H 2 S-releasing NSAIDs are very well tolerated throughout the GI tract, even when co-administered with other drugs (e.g., aspirin, proton pump inhibitors) that significantly increase small intestinal damage. Pre-clinical studies in multiple species have confirmed the safety of H 2 S-releasing NSAIDs, supporting the initiation of human clinical trials." @default.
- W2023394669 created "2016-06-24" @default.
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- W2023394669 date "2014-05-01" @default.
- W2023394669 modified "2023-09-25" @default.
- W2023394669 title "S5-1 H2S-based therapeutics for inflammatory diseases" @default.
- W2023394669 doi "https://doi.org/10.1016/j.niox.2014.03.021" @default.
- W2023394669 hasPublicationYear "2014" @default.
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