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• W2023395517 abstract "A series of boron-containing nicotine (NIC) analogues 7-9 was synthesized and evaluated for binding to alpha4beta2 and alpha7 nicotinic receptors. Compound ACME-B inhibited [3H]methyllycaconitine binding to rat brain membranes with a similar potency compared to NIC (Ki = 2.4 and 0.77 microM, respectively), but was markedly less potent in inhibiting [3H]NIC binding when compared to NIC (Ki = 0.60 microM and 1.0 nM, respectively). Thus, tethering a two-carbon bridge between the 2-pyridyl and 3'-pyrrolidino carbons of NIC or 7 affords analogues that bind to the alpha7 receptor in a manner similar to NIC, but with a dramatic loss of affinity for the alpha4beta2 receptor." @default.
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• W2023395517 date "2001-05-01" @default.
• W2023395517 modified "2023-09-27" @default.
• W2023395517 title "Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues" @default.
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• W2023395517 doi "https://doi.org/10.1016/s0960-894x(01)00193-7" @default.
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