Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023397244> ?p ?o ?g. }
- W2023397244 endingPage "1038" @default.
- W2023397244 startingPage "1031" @default.
- W2023397244 abstract "Abstract Immune responses to pathogens need to be maintained within appropriate levels to minimize tissue damage, whereas such controlled immunity may allow persistent infection of certain types of pathogens. Interleukin 10 (IL-10) plays an important role in such immune regulation. We previously showed that HSV-stimulated human plasmacytoid dendritic cells (pDCs) induced naive CD4+ T cells to differentiate into interferon γ (IFN-γ)/IL-10–producing T cells. Here we show that HSV-stimulated pDCs induce allogeneic naive CD4+ T cells to differentiate into cytotoxic regulatory T cells that poorly proliferate on restimulation and inhibit proliferation of coexisting naive CD4+ T cells. IL-3–stimulated pDCs or myeloid DCs did not induce such regulatory T cells. Both IFN-α and IL-10 were responsible for the induction of anergic and regulatory properties. High percentages of CD4+ T cells cocultured with HSV-stimulated pDCs, and to a lesser extent those cocultured with IL-3–stimulated pDCs, expressed granzyme B and perforin in an IL-10–dependent manner. CD4+ T cells cocultured with HSV-stimulated pDCs accordingly exhibited cytotoxic activity. The finding that virus-stimulated pDCs are capable of inducing CD4+ cytotoxic regulatory T cells suggests that this DC subset may play an important role in suppressing excessive inflammatory responses and also in inducing persistent viral infection." @default.
- W2023397244 created "2016-06-24" @default.
- W2023397244 creator A5007124268 @default.
- W2023397244 creator A5017667781 @default.
- W2023397244 creator A5021248501 @default.
- W2023397244 creator A5090509475 @default.
- W2023397244 date "2006-02-01" @default.
- W2023397244 modified "2023-10-13" @default.
- W2023397244 title "Virus-stimulated plasmacytoid dendritic cells induce CD4+ cytotoxic regulatory T cells" @default.
- W2023397244 cites W1517310071 @default.
- W2023397244 cites W1526621387 @default.
- W2023397244 cites W1636291108 @default.
- W2023397244 cites W1830155866 @default.
- W2023397244 cites W1945216762 @default.
- W2023397244 cites W1965580605 @default.
- W2023397244 cites W1968492586 @default.
- W2023397244 cites W1981746803 @default.
- W2023397244 cites W1986315531 @default.
- W2023397244 cites W1991344211 @default.
- W2023397244 cites W1994111355 @default.
- W2023397244 cites W1995900768 @default.
- W2023397244 cites W2000768335 @default.
- W2023397244 cites W2002726823 @default.
- W2023397244 cites W2003269304 @default.
- W2023397244 cites W2004829503 @default.
- W2023397244 cites W2021165722 @default.
- W2023397244 cites W2024118972 @default.
- W2023397244 cites W2041345462 @default.
- W2023397244 cites W2048991194 @default.
- W2023397244 cites W2061021775 @default.
- W2023397244 cites W2065217848 @default.
- W2023397244 cites W2067648924 @default.
- W2023397244 cites W2095040060 @default.
- W2023397244 cites W2104357791 @default.
- W2023397244 cites W2104904748 @default.
- W2023397244 cites W2108860192 @default.
- W2023397244 cites W2110030347 @default.
- W2023397244 cites W2111220263 @default.
- W2023397244 cites W2116394003 @default.
- W2023397244 cites W2116716017 @default.
- W2023397244 cites W2116723397 @default.
- W2023397244 cites W2118756315 @default.
- W2023397244 cites W2121250603 @default.
- W2023397244 cites W2121835123 @default.
- W2023397244 cites W2136245823 @default.
- W2023397244 cites W2137594178 @default.
- W2023397244 cites W2138235536 @default.
- W2023397244 cites W2143565660 @default.
- W2023397244 cites W2145424103 @default.
- W2023397244 cites W2148178789 @default.
- W2023397244 cites W2158722408 @default.
- W2023397244 cites W2163007870 @default.
- W2023397244 cites W2171190856 @default.
- W2023397244 doi "https://doi.org/10.1182/blood-2005-04-1737" @default.
- W2023397244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16219801" @default.
- W2023397244 hasPublicationYear "2006" @default.
- W2023397244 type Work @default.
- W2023397244 sameAs 2023397244 @default.
- W2023397244 citedByCount "106" @default.
- W2023397244 countsByYear W20233972442012 @default.
- W2023397244 countsByYear W20233972442013 @default.
- W2023397244 countsByYear W20233972442014 @default.
- W2023397244 countsByYear W20233972442015 @default.
- W2023397244 countsByYear W20233972442016 @default.
- W2023397244 countsByYear W20233972442017 @default.
- W2023397244 countsByYear W20233972442019 @default.
- W2023397244 countsByYear W20233972442020 @default.
- W2023397244 countsByYear W20233972442021 @default.
- W2023397244 countsByYear W20233972442022 @default.
- W2023397244 crossrefType "journal-article" @default.
- W2023397244 hasAuthorship W2023397244A5007124268 @default.
- W2023397244 hasAuthorship W2023397244A5017667781 @default.
- W2023397244 hasAuthorship W2023397244A5021248501 @default.
- W2023397244 hasAuthorship W2023397244A5090509475 @default.
- W2023397244 hasBestOaLocation W20233972441 @default.
- W2023397244 hasConcept C129374314 @default.
- W2023397244 hasConcept C149532602 @default.
- W2023397244 hasConcept C154317977 @default.
- W2023397244 hasConcept C167672396 @default.
- W2023397244 hasConcept C183193105 @default.
- W2023397244 hasConcept C202751555 @default.
- W2023397244 hasConcept C203014093 @default.
- W2023397244 hasConcept C2776062744 @default.
- W2023397244 hasConcept C2776090121 @default.
- W2023397244 hasConcept C2780380082 @default.
- W2023397244 hasConcept C55493867 @default.
- W2023397244 hasConcept C67662055 @default.
- W2023397244 hasConcept C79484868 @default.
- W2023397244 hasConcept C86803240 @default.
- W2023397244 hasConcept C8891405 @default.
- W2023397244 hasConceptScore W2023397244C129374314 @default.
- W2023397244 hasConceptScore W2023397244C149532602 @default.
- W2023397244 hasConceptScore W2023397244C154317977 @default.
- W2023397244 hasConceptScore W2023397244C167672396 @default.
- W2023397244 hasConceptScore W2023397244C183193105 @default.
- W2023397244 hasConceptScore W2023397244C202751555 @default.
- W2023397244 hasConceptScore W2023397244C203014093 @default.
- W2023397244 hasConceptScore W2023397244C2776062744 @default.