FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023398972> ?p ?o ?g. }

• W2023398972 abstract "Epiretinal implants based on microelectro-mechanical system (MEMS) technology with a polyimide (PI) material are being proposed for application. Many kinds of non-photosensitive PIs have good biocompatibility and stability as typical MEMS materials for implantable electrodes. However, the effects of MEMS microfabrication, sterilization and implantation using a photosensitive polyimide (PSPI) microelectrode array for epiretinal electrical stimulation has not been extensively examined.A novel PSPI (Durimide 7510) microelectrode array for epiretinal electrical stimulation was designed, fabricated based on MEMS processing and microfabrication techniques. The biocompatibility of our new microelectrode was tested in vitro using an MTT assay and direct contact tests between the microelectrode surface and cells. Electrochemical impedance characteristics were tested based on a three-electrode testing method. The reliability and stability was evaluated by a chronic implantation of a non-functional array within the rabbit eye. Histological examination and SEM were performed to monitor possible damage of the retina and microelectrodes. Electrically evoked potentials (EEPs) were recorded during the acute stimulation of the retina.The substrate was made of PSPI and the electrode material was platinum (Pt). The PSPI microelectrode array showed good biocompatibility and appropriate impedance characteristics for epiretinal stimulation. After a 6-month epiretinal implantation in the eyes of rabbits, we found no local retinal toxicity and no mechanical compression caused by the array. The Pt electrodes adhesion to the PSPI remained stable. A response to electrical stimuli was with recording electrodes lying on the visual cortex.We provide a relevant design and fundamental characteristics of a PSPI microelectrode array. Strong evidences on testing indicate that implantation is safe in terms of mechanical pressure and biocompatibility of PSPI microelectrode arrays on the retina. The dual-layer process we used proffers considerable advantages over the more traditional single-layer approach and can accommodate much many electrode sites. This lays the groundwork for a future, high-resolution retinal prosthesis with many more electrode sites based on the flexible PSPI thin film substrate." @default.
• W2023398972 created "2016-06-24" @default.
• W2023398972 creator A5001794046 @default.
• W2023398972 creator A5004363029 @default.
• W2023398972 creator A5018389659 @default.
• W2023398972 creator A5048411184 @default.
• W2023398972 creator A5050942599 @default.
• W2023398972 creator A5058779185 @default.
• W2023398972 creator A5069507396 @default.
• W2023398972 creator A5090792141 @default.
• W2023398972 date "2013-05-29" @default.
• W2023398972 modified "2023-10-11" @default.
• W2023398972 title "In vitro and in vivo evaluation of a photosensitive polyimide thin-film microelectrode array suitable for epiretinal stimulation" @default.
• W2023398972 cites W1973442396 @default.
• W2023398972 cites W1976610950 @default.
• W2023398972 cites W2014310324 @default.
• W2023398972 cites W2016006796 @default.
• W2023398972 cites W2033305192 @default.
• W2023398972 cites W2033599059 @default.
• W2023398972 cites W2033812657 @default.
• W2023398972 cites W2041680390 @default.
• W2023398972 cites W2045851428 @default.
• W2023398972 cites W2047497020 @default.
• W2023398972 cites W2051923857 @default.
• W2023398972 cites W2085314272 @default.
• W2023398972 cites W2086069830 @default.
• W2023398972 cites W2092445190 @default.
• W2023398972 cites W2106987596 @default.
• W2023398972 cites W2114918609 @default.
• W2023398972 cites W2116074682 @default.
• W2023398972 cites W2118257779 @default.
• W2023398972 cites W2125906494 @default.
• W2023398972 cites W2131773286 @default.
• W2023398972 cites W2139293774 @default.
• W2023398972 cites W2153552284 @default.
• W2023398972 cites W2156252917 @default.
• W2023398972 cites W2170459269 @default.
• W2023398972 cites W4248262636 @default.
• W2023398972 cites W4251992482 @default.
• W2023398972 doi "https://doi.org/10.1186/1743-0003-10-48" @default.
• W2023398972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3671245" @default.
• W2023398972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23718827" @default.
• W2023398972 hasPublicationYear "2013" @default.
• W2023398972 type Work @default.
• W2023398972 sameAs 2023398972 @default.
• W2023398972 citedByCount "29" @default.
• W2023398972 countsByYear W20233989722014 @default.
• W2023398972 countsByYear W20233989722015 @default.
• W2023398972 countsByYear W20233989722016 @default.
• W2023398972 countsByYear W20233989722017 @default.
• W2023398972 countsByYear W20233989722018 @default.
• W2023398972 countsByYear W20233989722019 @default.
• W2023398972 countsByYear W20233989722020 @default.
• W2023398972 countsByYear W20233989722021 @default.
• W2023398972 countsByYear W20233989722022 @default.
• W2023398972 countsByYear W20233989722023 @default.
• W2023398972 crossrefType "journal-article" @default.
• W2023398972 hasAuthorship W2023398972A5001794046 @default.
• W2023398972 hasAuthorship W2023398972A5004363029 @default.
• W2023398972 hasAuthorship W2023398972A5018389659 @default.
• W2023398972 hasAuthorship W2023398972A5048411184 @default.
• W2023398972 hasAuthorship W2023398972A5050942599 @default.
• W2023398972 hasAuthorship W2023398972A5058779185 @default.
• W2023398972 hasAuthorship W2023398972A5069507396 @default.
• W2023398972 hasAuthorship W2023398972A5090792141 @default.
• W2023398972 hasBestOaLocation W20233989721 @default.
• W2023398972 hasConcept C111670793 @default.
• W2023398972 hasConcept C136229726 @default.
• W2023398972 hasConcept C136525101 @default.
• W2023398972 hasConcept C142724271 @default.
• W2023398972 hasConcept C147789679 @default.
• W2023398972 hasConcept C171250308 @default.
• W2023398972 hasConcept C17525397 @default.
• W2023398972 hasConcept C185592680 @default.
• W2023398972 hasConcept C191897082 @default.
• W2023398972 hasConcept C192562407 @default.
• W2023398972 hasConcept C204787440 @default.
• W2023398972 hasConcept C2777230088 @default.
• W2023398972 hasConcept C2779227376 @default.
• W2023398972 hasConcept C2780965675 @default.
• W2023398972 hasConcept C37977207 @default.
• W2023398972 hasConcept C527607 @default.
• W2023398972 hasConcept C71924100 @default.
• W2023398972 hasConcept C95967509 @default.
• W2023398972 hasConceptScore W2023398972C111670793 @default.
• W2023398972 hasConceptScore W2023398972C136229726 @default.
• W2023398972 hasConceptScore W2023398972C136525101 @default.
• W2023398972 hasConceptScore W2023398972C142724271 @default.
• W2023398972 hasConceptScore W2023398972C147789679 @default.
• W2023398972 hasConceptScore W2023398972C171250308 @default.
• W2023398972 hasConceptScore W2023398972C17525397 @default.
• W2023398972 hasConceptScore W2023398972C185592680 @default.
• W2023398972 hasConceptScore W2023398972C191897082 @default.
• W2023398972 hasConceptScore W2023398972C192562407 @default.
• W2023398972 hasConceptScore W2023398972C204787440 @default.
• W2023398972 hasConceptScore W2023398972C2777230088 @default.
• W2023398972 hasConceptScore W2023398972C2779227376 @default.
• W2023398972 hasConceptScore W2023398972C2780965675 @default.
• W2023398972 hasConceptScore W2023398972C37977207 @default.
• W2023398972 hasConceptScore W2023398972C527607 @default.

• next