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• W2023401515 abstract "Because of the known activity of interleukin-5 (IL-5) as a growth factor for human eosinophils, we performed studies to ascertain whether M4Eo acute leukemia cells might be capable of responding to IL-5. Surprisingly, short term incubation of freshly isolated M4Eo blasts with rhIL-5 induced differentiation of the cells to macrophages. To determine whether other variants of acute myelogenous leukemia (AML) might also be capable of responding to IL-5, we studied cells from four additional unselected cases and found that one responded to IL-5 by vigorous proliferation. Using biotinylated rhIL-5, second labelling with streptavidin-fluorescein isothiocyanate (FITC) and flow cytometric analysis, specific binding of IL-5 to both responsive leukemias was demonstrated, suggesting the presence of specific IL-5 receptors. Additional study will be needed to assess the frequency of IL-5 responsiveness in AML and to determine the relationship of these phenomena to the physiologic role of IL-5 in the regulation of hematopoiesis." @default.
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• W2023401515 date "1992-04-01" @default.
• W2023401515 modified "2023-10-18" @default.
• W2023401515 title "Effects of interleukin-5 on acute myeloid leukemias" @default.
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• W2023401515 doi "https://doi.org/10.1002/ajh.2830390407" @default.
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