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• W2023401600 abstract "Peroxynitrite (ONOO(-)), formed from the reaction of superoxide ((*)O(2)(-)) and nitric oxide ((*)NO), induces cellular and tissue injury, resulting in several human diseases such as stroke, Alzheimer's disease, and atherosclerosis. Due to the lack of endogenous enzymes responsible for ONOO(-) scavenging activity, finding a specific ONOO(-) scavenger is of considerable importance. In this study we examined the scavenging effects of zingerone from ginger against ONOO(-), intracellular RS (reactive species), and ONOO(-). The data show that zingerone can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1). Zingerone inhibited the formation of ONOO(-)-mediated tyrosine nitration through electron donation, nitration of bovine serum albumin (BSA) by ONOO(-), and intracellular RS and ONOO(-). The present study suggests that zingerone has an efficient ONOO(-) scavenging ability, which may be a potent ONOO(-) scavenger for the protection of the cellular defense activity against ONOO(-)- involved diseases." @default.
• W2023401600 created "2016-06-24" @default.
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• W2023401600 date "2005-08-19" @default.
• W2023401600 modified "2023-09-26" @default.
• W2023401600 title "Zingerone as an Antioxidant against Peroxynitrite" @default.
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• W2023401600 doi "https://doi.org/10.1021/jf051014x" @default.
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