Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023401876> ?p ?o ?g. }
- W2023401876 abstract "Peroxisome proliferator-activated receptor gamma (PPARγ) responds to thiazolidinedione derivatives, which are ligands of PPARγ, and affects insulin resistance. Recently, a PPARγ study reported that in high-fat-diet-induced obesity, the phosphorylation of PPARγ prevented the transcription of specific PPARγ targets that have anti-obesity effects. We previously reported that genetic variants of the fatty acid desaturase were associated with plasma lipid profiles and could contribute to dyslipidemia in Japanese males. The aim of this study was to investigate the anti-obesity effects of PPARγ variants on lipid profiles. One hundred and thirty-eight (138) Japanese males participated in the study. Their serum lipid markers and the fatty acid composition of their red blood cell (RBC) membranes were determined. The stearoyl-CoA desaturase 1 (SCD1) indices were represented as the fatty acid product : precursor ratios. The participants were genotyped for the single-nucleotide polymorphism rs2938392 in the PPARγ gene. The participants' fitness habits were also surveyed by questionnaire. The effects of habitual exercise on the measured lipid parameters were compared in each genotype group. No association between the genotypes in the PPARγ gene and the biochemical data was found. However, the serum triglyceride levels and the SCD1 indices in RBC membranes were significantly higher in the participants who carried the major rs2938392 allele (A/A) and did not habitually exercise than in those who did exercise. These findings indicate that the risk for detrimental lipid profiles in the absence of habitual exercise depends on the PPARγ genotype in Japanese males." @default.
- W2023401876 created "2016-06-24" @default.
- W2023401876 creator A5003330286 @default.
- W2023401876 creator A5011811795 @default.
- W2023401876 creator A5042480948 @default.
- W2023401876 creator A5050075457 @default.
- W2023401876 creator A5064825030 @default.
- W2023401876 creator A5064895846 @default.
- W2023401876 creator A5066733681 @default.
- W2023401876 creator A5067858714 @default.
- W2023401876 creator A5072785004 @default.
- W2023401876 creator A5087814758 @default.
- W2023401876 date "2014-01-01" @default.
- W2023401876 modified "2023-10-06" @default.
- W2023401876 title "Efficacy of Habitual Exercise for Improving Lipid Profiles Depends on the PPRA^|^gamma; Genotype in Japanese Males" @default.
- W2023401876 cites W1939555998 @default.
- W2023401876 cites W1966394156 @default.
- W2023401876 cites W1968900393 @default.
- W2023401876 cites W1974223060 @default.
- W2023401876 cites W2007547815 @default.
- W2023401876 cites W2011796043 @default.
- W2023401876 cites W2036578487 @default.
- W2023401876 cites W2045097753 @default.
- W2023401876 cites W2051868844 @default.
- W2023401876 cites W2052513772 @default.
- W2023401876 cites W2105653570 @default.
- W2023401876 cites W2135009079 @default.
- W2023401876 cites W2136715884 @default.
- W2023401876 cites W2151077326 @default.
- W2023401876 cites W2164707581 @default.
- W2023401876 cites W2216457179 @default.
- W2023401876 doi "https://doi.org/10.3177/jnsv.60.66" @default.
- W2023401876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24759262" @default.
- W2023401876 hasPublicationYear "2014" @default.
- W2023401876 type Work @default.
- W2023401876 sameAs 2023401876 @default.
- W2023401876 citedByCount "0" @default.
- W2023401876 crossrefType "journal-article" @default.
- W2023401876 hasAuthorship W2023401876A5003330286 @default.
- W2023401876 hasAuthorship W2023401876A5011811795 @default.
- W2023401876 hasAuthorship W2023401876A5042480948 @default.
- W2023401876 hasAuthorship W2023401876A5050075457 @default.
- W2023401876 hasAuthorship W2023401876A5064825030 @default.
- W2023401876 hasAuthorship W2023401876A5064895846 @default.
- W2023401876 hasAuthorship W2023401876A5066733681 @default.
- W2023401876 hasAuthorship W2023401876A5067858714 @default.
- W2023401876 hasAuthorship W2023401876A5072785004 @default.
- W2023401876 hasAuthorship W2023401876A5087814758 @default.
- W2023401876 hasBestOaLocation W20234018761 @default.
- W2023401876 hasConcept C104317684 @default.
- W2023401876 hasConcept C126322002 @default.
- W2023401876 hasConcept C134018914 @default.
- W2023401876 hasConcept C135763542 @default.
- W2023401876 hasConcept C153209595 @default.
- W2023401876 hasConcept C170493617 @default.
- W2023401876 hasConcept C187345961 @default.
- W2023401876 hasConcept C19038510 @default.
- W2023401876 hasConcept C2777129432 @default.
- W2023401876 hasConcept C2777391703 @default.
- W2023401876 hasConcept C2778096610 @default.
- W2023401876 hasConcept C2778163477 @default.
- W2023401876 hasConcept C2778913445 @default.
- W2023401876 hasConcept C4733338 @default.
- W2023401876 hasConcept C511355011 @default.
- W2023401876 hasConcept C543025807 @default.
- W2023401876 hasConcept C55493867 @default.
- W2023401876 hasConcept C71924100 @default.
- W2023401876 hasConcept C86803240 @default.
- W2023401876 hasConceptScore W2023401876C104317684 @default.
- W2023401876 hasConceptScore W2023401876C126322002 @default.
- W2023401876 hasConceptScore W2023401876C134018914 @default.
- W2023401876 hasConceptScore W2023401876C135763542 @default.
- W2023401876 hasConceptScore W2023401876C153209595 @default.
- W2023401876 hasConceptScore W2023401876C170493617 @default.
- W2023401876 hasConceptScore W2023401876C187345961 @default.
- W2023401876 hasConceptScore W2023401876C19038510 @default.
- W2023401876 hasConceptScore W2023401876C2777129432 @default.
- W2023401876 hasConceptScore W2023401876C2777391703 @default.
- W2023401876 hasConceptScore W2023401876C2778096610 @default.
- W2023401876 hasConceptScore W2023401876C2778163477 @default.
- W2023401876 hasConceptScore W2023401876C2778913445 @default.
- W2023401876 hasConceptScore W2023401876C4733338 @default.
- W2023401876 hasConceptScore W2023401876C511355011 @default.
- W2023401876 hasConceptScore W2023401876C543025807 @default.
- W2023401876 hasConceptScore W2023401876C55493867 @default.
- W2023401876 hasConceptScore W2023401876C71924100 @default.
- W2023401876 hasConceptScore W2023401876C86803240 @default.
- W2023401876 hasLocation W20234018761 @default.
- W2023401876 hasLocation W20234018762 @default.
- W2023401876 hasOpenAccess W2023401876 @default.
- W2023401876 hasPrimaryLocation W20234018761 @default.
- W2023401876 hasRelatedWork W1894700821 @default.
- W2023401876 hasRelatedWork W1997338705 @default.
- W2023401876 hasRelatedWork W2023154173 @default.
- W2023401876 hasRelatedWork W2028009073 @default.
- W2023401876 hasRelatedWork W2088408940 @default.
- W2023401876 hasRelatedWork W2143004231 @default.
- W2023401876 hasRelatedWork W2163187036 @default.
- W2023401876 hasRelatedWork W2347839228 @default.
- W2023401876 hasRelatedWork W2370591872 @default.