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• W2023402207 abstract "Summary Aim : To compare the efficacy of different regimens in patients in whom previous Helicobacter pylori eradication therapy has failed. Methods : In this study named StratHegy patients ( n = 287) were randomized to receive one of three empirical triple therapy regimens or a strategy based on antibiotic susceptibility. The empirical regimens were omeprazole, 20 mg b.d., plus amoxicillin, 1000 mg b.d., and clarithromycin, 500 mg b.d., for 7 days (OAC 7 ), clarithromycin, 500 mg b.d., for 14 days (OAC 14 ) or metronidazole, 500 mg b.d., for 14 days (OAM 14 ). In the susceptibility‐based strategy, patients with clarithromycin‐susceptible strains received OAC 14 , whilst the others received OAM 14 . The 13 C‐urea breath test was performed before randomization and 4–5 weeks after eradication therapy. Results : In the intention‐to‐treat analysis, the eradication rates for empirical therapies were as follows: OAC 7 , 47.4% (27/57); OAC 14 , 34.5% (20/58); OAM 14 , 63.2% (36/57); it was 74.3% (84/113) for the susceptibility‐based treatment ( P < 0.01 when compared with OAC 7 and OAC 14 ). In patients receiving clarithromycin, the eradication rates were 80% for clarithromycin‐susceptible strains and 16% for clarithromycin‐resistant strains; in patients receiving OAM 14 , the eradication rates were 81% for metronidazole‐susceptible strains and 59% for metronidazole‐resistant strains. Conclusions : Eradication rates of approximately 75% can be achieved with second‐line triple therapy based on antibiotic susceptibility testing. If susceptibility testing is not available, OAM 14 is an appropriate alternative." @default.
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• W2023402207 date "2003-09-19" @default.
• W2023402207 modified "2023-10-18" @default.
• W2023402207 title "Second-line treatment for failure to eradicate Helicobacter pylori: a randomized trial comparing four treatment strategies" @default.
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• W2023402207 doi "https://doi.org/10.1046/j.1365-2036.2003.01759.x" @default.
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