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- W2023402667 abstract "Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. It is believed to arise from skeletal muscle progenitors, preserving the expression of genes critical for embryonic myogenic development such as MYOD1 and myogenin . RMS is classified as embryonal, which is more common in younger children, or alveolar, which is more prevalent in elder children and adults. Despite aggressive management including surgery, radiation, and chemotherapy, the outcome for children with metastatic RMS is dismal, and the prognosis has remained unchanged for decades. Apoptosis is a highly regulated process critical for embryonic development and tissue and organ homeostasis. Like other types of cancers, RMS develops by evading intrinsic apoptosis via mutations in the p53 tumor suppressor gene. However, the ability to induce apoptosis via the death receptor-dependent extrinsic pathway remains largely intact in tumors with p53 mutations. This paper focuses on activating extrinsic apoptosis as a therapeutic strategy for RMS by targeting the death receptor DR5 with a recombinant TRAIL ligand or agonistic antibodies directed against DR5." @default.
- W2023402667 created "2016-06-24" @default.
- W2023402667 creator A5022570940 @default.
- W2023402667 creator A5026986071 @default.
- W2023402667 creator A5056877439 @default.
- W2023402667 date "2012-04-17" @default.
- W2023402667 modified "2023-09-25" @default.
- W2023402667 title "Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma" @default.
- W2023402667 cites W1484817497 @default.
- W2023402667 cites W1493702629 @default.
- W2023402667 cites W1650797637 @default.
- W2023402667 cites W1938362079 @default.
- W2023402667 cites W1964304371 @default.
- W2023402667 cites W1964661396 @default.
- W2023402667 cites W1965948555 @default.
- W2023402667 cites W1966150411 @default.
- W2023402667 cites W1966802202 @default.
- W2023402667 cites W1967051322 @default.
- W2023402667 cites W1971895570 @default.
- W2023402667 cites W1972936270 @default.
- W2023402667 cites W1973109581 @default.
- W2023402667 cites W1979319210 @default.
- W2023402667 cites W1983645982 @default.
- W2023402667 cites W1984554785 @default.
- W2023402667 cites W1987432765 @default.
- W2023402667 cites W1987506447 @default.
- W2023402667 cites W1991388076 @default.
- W2023402667 cites W1991628301 @default.
- W2023402667 cites W1993129579 @default.
- W2023402667 cites W1994269886 @default.
- W2023402667 cites W2005246279 @default.
- W2023402667 cites W2005542290 @default.
- W2023402667 cites W2008725666 @default.
- W2023402667 cites W2009085926 @default.
- W2023402667 cites W2009183786 @default.
- W2023402667 cites W2010958626 @default.
- W2023402667 cites W2013910960 @default.
- W2023402667 cites W2015334004 @default.
- W2023402667 cites W2016544505 @default.
- W2023402667 cites W2017073563 @default.
- W2023402667 cites W2018116689 @default.
- W2023402667 cites W2023342930 @default.
- W2023402667 cites W2027882342 @default.
- W2023402667 cites W2034269086 @default.
- W2023402667 cites W2037100222 @default.
- W2023402667 cites W2038118195 @default.
- W2023402667 cites W2039805273 @default.
- W2023402667 cites W2044970136 @default.
- W2023402667 cites W2045773193 @default.
- W2023402667 cites W2046424185 @default.
- W2023402667 cites W2047111725 @default.
- W2023402667 cites W2047972729 @default.
- W2023402667 cites W2050693077 @default.
- W2023402667 cites W2052688181 @default.
- W2023402667 cites W2057188721 @default.
- W2023402667 cites W2061403825 @default.
- W2023402667 cites W2062949984 @default.
- W2023402667 cites W2063669247 @default.
- W2023402667 cites W2067534266 @default.
- W2023402667 cites W2072380594 @default.
- W2023402667 cites W2074106785 @default.
- W2023402667 cites W2074501845 @default.
- W2023402667 cites W2078581194 @default.
- W2023402667 cites W2079463756 @default.
- W2023402667 cites W2087590198 @default.
- W2023402667 cites W2097786201 @default.
- W2023402667 cites W2100950671 @default.
- W2023402667 cites W2103648100 @default.
- W2023402667 cites W2103690933 @default.
- W2023402667 cites W2105466207 @default.
- W2023402667 cites W2105555467 @default.
- W2023402667 cites W2105733547 @default.
- W2023402667 cites W2108966286 @default.
- W2023402667 cites W2116595455 @default.
- W2023402667 cites W2117087670 @default.
- W2023402667 cites W2117476538 @default.
- W2023402667 cites W2117692326 @default.
- W2023402667 cites W2118271123 @default.
- W2023402667 cites W2125058702 @default.
- W2023402667 cites W2133221875 @default.
- W2023402667 cites W2133283258 @default.
- W2023402667 cites W2134486128 @default.
- W2023402667 cites W2138393270 @default.
- W2023402667 cites W2139952278 @default.
- W2023402667 cites W2143583402 @default.
- W2023402667 cites W2153442184 @default.
- W2023402667 cites W2154783588 @default.
- W2023402667 cites W2156330379 @default.
- W2023402667 cites W2159999972 @default.
- W2023402667 cites W2160246583 @default.
- W2023402667 cites W2160417212 @default.
- W2023402667 cites W2162574319 @default.
- W2023402667 cites W2169826773 @default.
- W2023402667 cites W2315764107 @default.
- W2023402667 cites W2321395951 @default.
- W2023402667 cites W2334948925 @default.
- W2023402667 cites W4230141536 @default.
- W2023402667 cites W4239395890 @default.