Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023402735> ?p ?o ?g. }
- W2023402735 endingPage "816" @default.
- W2023402735 startingPage "816" @default.
- W2023402735 abstract "Hypothermia has long been known to be a potent putative neuroprotectant. Experimental evidence and clinical experience show that hypothermia protects the brain from cerebral injury. Recent insights into the mechanisms of cerebral ischemia and reperfusion suggest reasons why hypothermia may be an ideal modality for stroke therapy. Hypothermia protects brain tissue in multiple ways. It retards energy depletion, reduces intracellular acidosis, lessens the ischemia related accumulation of excitotoxic neurotransmitters, and attenuates the influx of intracellular calcium. Additionally, hypothermia suppresses the generation of oxygen free radicals involved in secondary damage associated with reperfusion. It also suppresses the mechanisms related to blood-brain barrier degeneration and postischemic remodeling. The clinical application of therapeutic hypothermia and its limitations will be summarized in this paper. Therapeutic hypothermia is likely to undergo phase III clinical trials in various clinical settings. Novel technologies are being developed to optimize the safety and efficacy of this promising approach." @default.
- W2023402735 created "2016-06-24" @default.
- W2023402735 creator A5021809579 @default.
- W2023402735 date "2007-01-01" @default.
- W2023402735 modified "2023-09-23" @default.
- W2023402735 title "Therapeutic hypothermia: neuroprotective mechanisms" @default.
- W2023402735 cites W1493198062 @default.
- W2023402735 cites W1529872930 @default.
- W2023402735 cites W1546165821 @default.
- W2023402735 cites W1554837737 @default.
- W2023402735 cites W1857364306 @default.
- W2023402735 cites W1964349082 @default.
- W2023402735 cites W1965474870 @default.
- W2023402735 cites W1968008458 @default.
- W2023402735 cites W1969585993 @default.
- W2023402735 cites W1970612718 @default.
- W2023402735 cites W1971924425 @default.
- W2023402735 cites W1973406593 @default.
- W2023402735 cites W1974661112 @default.
- W2023402735 cites W1974867595 @default.
- W2023402735 cites W1976329162 @default.
- W2023402735 cites W1976807374 @default.
- W2023402735 cites W1978121449 @default.
- W2023402735 cites W1979911662 @default.
- W2023402735 cites W1981082943 @default.
- W2023402735 cites W1981284566 @default.
- W2023402735 cites W1983131360 @default.
- W2023402735 cites W1984287655 @default.
- W2023402735 cites W1990139311 @default.
- W2023402735 cites W1990375791 @default.
- W2023402735 cites W1991207312 @default.
- W2023402735 cites W1992755028 @default.
- W2023402735 cites W1992975079 @default.
- W2023402735 cites W1994909968 @default.
- W2023402735 cites W1997681415 @default.
- W2023402735 cites W1997839952 @default.
- W2023402735 cites W1998079511 @default.
- W2023402735 cites W1999405560 @default.
- W2023402735 cites W2004315235 @default.
- W2023402735 cites W2007369723 @default.
- W2023402735 cites W2008490486 @default.
- W2023402735 cites W2010027846 @default.
- W2023402735 cites W2012028805 @default.
- W2023402735 cites W2012265886 @default.
- W2023402735 cites W2013182924 @default.
- W2023402735 cites W2013922867 @default.
- W2023402735 cites W2014147678 @default.
- W2023402735 cites W2014230589 @default.
- W2023402735 cites W2015667316 @default.
- W2023402735 cites W2016198009 @default.
- W2023402735 cites W2020874295 @default.
- W2023402735 cites W2021331451 @default.
- W2023402735 cites W2021538987 @default.
- W2023402735 cites W2027845608 @default.
- W2023402735 cites W2029560538 @default.
- W2023402735 cites W2031199736 @default.
- W2023402735 cites W2031298646 @default.
- W2023402735 cites W2031955562 @default.
- W2023402735 cites W2033322546 @default.
- W2023402735 cites W2034293193 @default.
- W2023402735 cites W2036755665 @default.
- W2023402735 cites W2037085141 @default.
- W2023402735 cites W2038871533 @default.
- W2023402735 cites W2041486805 @default.
- W2023402735 cites W2043773466 @default.
- W2023402735 cites W2045663952 @default.
- W2023402735 cites W2046927411 @default.
- W2023402735 cites W2047034998 @default.
- W2023402735 cites W2047387664 @default.
- W2023402735 cites W2047393829 @default.
- W2023402735 cites W2048692124 @default.
- W2023402735 cites W2052813338 @default.
- W2023402735 cites W2053525375 @default.
- W2023402735 cites W2056479075 @default.
- W2023402735 cites W2057464278 @default.
- W2023402735 cites W2058022693 @default.
- W2023402735 cites W2059411233 @default.
- W2023402735 cites W2060017971 @default.
- W2023402735 cites W2060249985 @default.
- W2023402735 cites W2062642814 @default.
- W2023402735 cites W2064634626 @default.
- W2023402735 cites W2071256185 @default.
- W2023402735 cites W2071730783 @default.
- W2023402735 cites W2072001685 @default.
- W2023402735 cites W2072847038 @default.
- W2023402735 cites W2074895826 @default.
- W2023402735 cites W2076690232 @default.
- W2023402735 cites W207752629 @default.
- W2023402735 cites W2078568251 @default.
- W2023402735 cites W2078746887 @default.
- W2023402735 cites W2079847147 @default.
- W2023402735 cites W2080542534 @default.
- W2023402735 cites W2080656191 @default.
- W2023402735 cites W2081847864 @default.
- W2023402735 cites W2083863966 @default.
- W2023402735 cites W2087810871 @default.
- W2023402735 cites W2093495243 @default.
- W2023402735 cites W2096523744 @default.