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• W2023403043 abstract "Spermiogenesis in the mammalian testis is the most critical post-meiotic developmental event occurring during spermatogenesis in which haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa. Spermatozoa are then released from the seminiferous epithelium at spermiation. At the same time, the BTB (blood–testis barrier) undergoes restructuring to facilitate the transit of preleptotene spermatocytes from the basal to the apical compartment. Thus meiotic divisions take place behind the BTB in the apical compartment to form spermatids. These germ cells enter spermiogenesis to transform into elongating spermatids and then into spermatozoa to replace those that were released in the previous cycle. However, the mole-cular regulators that control spermiogenesis, in particular the dynamic changes that occur at the Sertoli cell–spermatid interface and at the BTB, are not entirely known. This is largely due to the lack of suitable animal models which can be used to study these events. During the course of our investigation to develop adjudin [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] as a potential male contraceptive, this drug was shown to ‘accelerate’ spermiation by inducing the release of premature spermatids from the epithelium. Using this model, we have identified several molecules that are crucial in regulating the actin filament network and the unique adhesion protein complex at the Sertoli cell–spermatid interface known as the apical ES (ectoplasmic specialization). In the present review, we critically evaluate these and other findings in the literature as they relate to the restricted temporal and spatial expression of two actin regulatory proteins, namely Eps8 (epidermal growth factor receptor pathway substrate 8) and Arp3 (actin-related protein 3), which regulate these events." @default.
• W2023403043 created "2016-06-24" @default.
• W2023403043 creator A5041273456 @default.
• W2023403043 creator A5072413923 @default.
• W2023403043 date "2011-04-13" @default.
• W2023403043 modified "2023-10-16" @default.
• W2023403043 title "Regulation of spermiogenesis, spermiation and blood–testis barrier dynamics: novel insights from studies on Eps8 and Arp3" @default.
• W2023403043 cites W1430767936 @default.
• W2023403043 cites W1510776906 @default.
• W2023403043 cites W1517625476 @default.
• W2023403043 cites W1579469490 @default.
• W2023403043 cites W1966021507 @default.
• W2023403043 cites W1966217830 @default.
• W2023403043 cites W1969911260 @default.
• W2023403043 cites W1970795622 @default.
• W2023403043 cites W1977874001 @default.
• W2023403043 cites W1978677736 @default.
• W2023403043 cites W1980143055 @default.
• W2023403043 cites W1982408362 @default.
• W2023403043 cites W1985594917 @default.
• W2023403043 cites W1986592841 @default.
• W2023403043 cites W1987082843 @default.
• W2023403043 cites W1988810304 @default.
• W2023403043 cites W1989309829 @default.
• W2023403043 cites W1991549216 @default.
• W2023403043 cites W1993083609 @default.
• W2023403043 cites W1995366061 @default.
• W2023403043 cites W1997228602 @default.
• W2023403043 cites W1997447186 @default.
• W2023403043 cites W1999495588 @default.
• W2023403043 cites W2000376389 @default.
• W2023403043 cites W2005537768 @default.
• W2023403043 cites W2006509394 @default.
• W2023403043 cites W2014913899 @default.
• W2023403043 cites W2016759352 @default.
• W2023403043 cites W2028444662 @default.
• W2023403043 cites W2028501521 @default.
• W2023403043 cites W2030994423 @default.
• W2023403043 cites W2032692532 @default.
• W2023403043 cites W2033184388 @default.
• W2023403043 cites W2033555492 @default.
• W2023403043 cites W2036254873 @default.
• W2023403043 cites W2038113907 @default.
• W2023403043 cites W2041263276 @default.
• W2023403043 cites W2041677910 @default.
• W2023403043 cites W2045527675 @default.
• W2023403043 cites W2046615366 @default.
• W2023403043 cites W2050440433 @default.
• W2023403043 cites W2055198035 @default.
• W2023403043 cites W2065959414 @default.
• W2023403043 cites W2069537490 @default.
• W2023403043 cites W2069644908 @default.
• W2023403043 cites W2071016907 @default.
• W2023403043 cites W2074685588 @default.
• W2023403043 cites W2075229853 @default.
• W2023403043 cites W2075765192 @default.
• W2023403043 cites W2076924967 @default.
• W2023403043 cites W2078532788 @default.
• W2023403043 cites W2079595896 @default.
• W2023403043 cites W2084073099 @default.
• W2023403043 cites W2093187124 @default.
• W2023403043 cites W2097825963 @default.
• W2023403043 cites W2105272775 @default.
• W2023403043 cites W2105802577 @default.
• W2023403043 cites W2108935114 @default.
• W2023403043 cites W2111904037 @default.
• W2023403043 cites W2112689688 @default.
• W2023403043 cites W2116176865 @default.
• W2023403043 cites W2117876140 @default.
• W2023403043 cites W2121150361 @default.
• W2023403043 cites W2121932601 @default.
• W2023403043 cites W2125863383 @default.
• W2023403043 cites W2127370867 @default.
• W2023403043 cites W2134957357 @default.
• W2023403043 cites W2138388305 @default.
• W2023403043 cites W2145367033 @default.
• W2023403043 cites W2149566322 @default.
• W2023403043 cites W2152944310 @default.
• W2023403043 cites W2153384288 @default.
• W2023403043 cites W2162553879 @default.
• W2023403043 cites W2163567894 @default.
• W2023403043 cites W2164698524 @default.
• W2023403043 cites W2164929923 @default.
• W2023403043 cites W2166234894 @default.
• W2023403043 cites W2252403865 @default.
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• W2023403043 doi "https://doi.org/10.1042/bj20102121" @default.
• W2023403043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4108193" @default.
• W2023403043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21486226" @default.
• W2023403043 hasPublicationYear "2011" @default.
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