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- W2023403486 abstract "It has been suggested that neuronal voltage‐sensitive calcium channels (VSCC) may be divided into dihydropyridine (DHP)‐sensitive (L) and DHP‐insensitive (N and T), and that both the L and the N type channels are attenuated by the peptide blocker ω‐conotoxin. Here the effects of ω‐conotoxin on release of noradrenaline and uptake of calcium in bovine adrenal chromaffin cells were investigated. Release of noradrenaline in response to 25 m m K + , 65 m m K + , 10 n m bradykinin or 10 μ m prostaglandin E 1 was not affected by ω‐conotoxin in the range 10 n m ‐1 μ m . 45 Ca 2+ uptake stimulated by high K + and prostaglandin was attenuated by 1 μ m nitrendipine and enhanced by 1 μ m Bay K 8644; these calcium fluxes were not modified by 20 n m ω‐conotoxin. With superfused rat brain striatal slices in the same medium as the above cell studies, release of dopamine in response to 25 m m K + was attenuated by 20 n m ω‐conotoxin. These results show that in these neurone‐like cells, release may be effected by calcium influx through DHP‐sensitive but ω‐conotoxin‐insensitive VSCC, a result inconsistent with the suggestion that ω‐conotoxin blocks both L‐type and N‐type neuronal calcium channels." @default.
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- W2023403486 date "1989-05-01" @default.
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- W2023403486 title "Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells" @default.
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- W2023403486 doi "https://doi.org/10.1111/j.1476-5381.1989.tb11933.x" @default.
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