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- W2023403718 abstract "One of the prominent consequences of the symbiogenic origin of eukaryotic cells is the unique presence of one particular class of phospholipids, cardiolipin (CL), in mitochondria. As the product originated from the evolution of symbiotic bacteria, CL is predominantly confined to the inner mitochondrial membrane in normally functioning cells. Recent findings identified CL and its oxidation products as important participants and signaling molecules in the apoptotic cell death program. Early in apoptosis, massive membrane translocations of CL take place resulting in its appearance in the outer mitochondrial membrane. Consequently, significant amounts of CL become available for the interactions with cyt c, one of the major proteins of the intermembrane space. Binding of CL with cytochrome c (cyt c) yields the cyt c/CL complex that acts as a potent CL-specific peroxidase and generates CL hydroperoxides. In this review, we discuss the catalytic mechanisms of CL oxidation by the peroxidase activity of cyt c as well as the role of oxidized CL (CLox) in the release of pro-apoptotic factors from mitochondria into the cytosol. Potential implications of cyt c/CL peroxidase intracellular complexes in disease conditions (cancer, neurodegeneration) are also considered. The discovery of the new role of cyt c/CL complexes in early mitochondrial apoptosis offers interesting opportunities for new targets in drug discovery programs. Finally, exit of cyt c from damaged and/or dying (apoptotic) cells into extracellular compartments and its accumulation in biofluids is discussed in lieu of the formation of its peroxidase complexes with negatively charged lipids and their significance in the development of systemic oxidative stress in circulation." @default.
- W2023403718 created "2016-06-24" @default.
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- W2023403718 date "2006-10-01" @default.
- W2023403718 modified "2023-10-17" @default.
- W2023403718 title "The “pro-apoptotic genies” get out of mitochondria: Oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes" @default.
- W2023403718 cites W1490805894 @default.
- W2023403718 cites W1501279037 @default.
- W2023403718 cites W1514650462 @default.
- W2023403718 cites W1527449265 @default.
- W2023403718 cites W1528360418 @default.
- W2023403718 cites W1551289009 @default.
- W2023403718 cites W1600980171 @default.
- W2023403718 cites W1926176532 @default.
- W2023403718 cites W1964734062 @default.
- W2023403718 cites W1964815111 @default.
- W2023403718 cites W1964879817 @default.
- W2023403718 cites W1965586048 @default.
- W2023403718 cites W1968091674 @default.
- W2023403718 cites W1968797108 @default.
- W2023403718 cites W1972482460 @default.
- W2023403718 cites W1972992613 @default.
- W2023403718 cites W1973147893 @default.
- W2023403718 cites W1973257737 @default.
- W2023403718 cites W1975783279 @default.
- W2023403718 cites W1977914031 @default.
- W2023403718 cites W1981261838 @default.
- W2023403718 cites W1982940971 @default.
- W2023403718 cites W1985956700 @default.
- W2023403718 cites W1986148909 @default.
- W2023403718 cites W1990906371 @default.
- W2023403718 cites W1994568480 @default.
- W2023403718 cites W1995629951 @default.
- W2023403718 cites W1999378703 @default.
- W2023403718 cites W1999445282 @default.
- W2023403718 cites W2001633727 @default.
- W2023403718 cites W2002088627 @default.
- W2023403718 cites W200511621 @default.
- W2023403718 cites W2008203769 @default.
- W2023403718 cites W2008265915 @default.
- W2023403718 cites W2008964882 @default.
- W2023403718 cites W2009279488 @default.
- W2023403718 cites W2011692072 @default.
- W2023403718 cites W2013543937 @default.
- W2023403718 cites W2016079109 @default.
- W2023403718 cites W2016445477 @default.
- W2023403718 cites W2017649638 @default.
- W2023403718 cites W2017697661 @default.
- W2023403718 cites W2018176211 @default.
- W2023403718 cites W2021122140 @default.
- W2023403718 cites W2022890158 @default.
- W2023403718 cites W2029701084 @default.
- W2023403718 cites W2030647828 @default.
- W2023403718 cites W2032233723 @default.
- W2023403718 cites W2032396876 @default.
- W2023403718 cites W2035215347 @default.
- W2023403718 cites W2035408510 @default.
- W2023403718 cites W2036573971 @default.
- W2023403718 cites W2038372638 @default.
- W2023403718 cites W2038568825 @default.
- W2023403718 cites W2039171411 @default.
- W2023403718 cites W2041459355 @default.
- W2023403718 cites W2042183674 @default.
- W2023403718 cites W2043716976 @default.
- W2023403718 cites W2044058641 @default.
- W2023403718 cites W2045093807 @default.
- W2023403718 cites W2047058597 @default.
- W2023403718 cites W2047160924 @default.
- W2023403718 cites W2057673505 @default.
- W2023403718 cites W2060981140 @default.
- W2023403718 cites W2062897750 @default.
- W2023403718 cites W2063018646 @default.
- W2023403718 cites W2063146732 @default.
- W2023403718 cites W2063362926 @default.
- W2023403718 cites W2064176864 @default.
- W2023403718 cites W2065382820 @default.
- W2023403718 cites W2065463667 @default.
- W2023403718 cites W2067262630 @default.
- W2023403718 cites W2067693365 @default.
- W2023403718 cites W2072377400 @default.
- W2023403718 cites W2073119484 @default.
- W2023403718 cites W2083504696 @default.
- W2023403718 cites W2090028980 @default.
- W2023403718 cites W2099103099 @default.
- W2023403718 cites W2100837269 @default.