FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023403785> ?p ?o ?g. }

• W2023403785 endingPage "431" @default.
• W2023403785 startingPage "418" @default.
• W2023403785 abstract "Bombesin is a potent inducer of signal trasduction pathways involved in the proliferation and invasion of androgen-insensitive prostatic tumor cells. This study examines the bombesin-mediated modulation of pericellular proteolysis, monitoring cell capability to migrate and invade basement membranes, using a chemo-invasion assay and analyzing protease production. The results suggest that bombesin could modulate the invasive potential of prostatic cell lines regulating secretion and cell-surface uptake of uPA and MMP-9 activation. In fact, in PC3 and DU145 cells but not in LNCaP cells, urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) are induced by bombesin treatment. Bombesin also stimulates cell proliferation and this effect can be inhibited blocking uPA by antibodies and/or uPA inhibitor p-aminobenzamidine. Moreover, HMW-uPA induces cell proliferation in LNCaP cells, which do not produce uPA in the basal conditions, while PC3 and DU145 cell growth is supported by autocrine production of uPA. The increment of uPA activity on the external plasma membrane causes an increased pericellular plasmin activation. This effect is inhibited by antibodies against uPA and by p-aminobenzamidine. Similarly to EGF, bombesin stimulates secretion and activation of MMP-9 and TIMP-1 production. MMP-9 activation can be also obtained by HMW-uPA treatment, suggesting that plasma-membrane-bound uPA can start a proteolytic cascade involving MMP-9. Therefore, in in vitro assays, bombesin is able to modulate pericellular proteolysis and cell proliferation, differently distributing and activating proteolytic activities. This effect can be related to the “non-random” degradation of the extracellular matrix in which membrane uPA-uPAreceptor complexes could start bombesin-induced directional protein degradation during metastatic spread. Int. J. Cancer 75:418–431, 1998. © 1998 Wiley-Liss, Inc." @default.
• W2023403785 created "2016-06-24" @default.
• W2023403785 creator A5002876711 @default.
• W2023403785 creator A5003696637 @default.
• W2023403785 creator A5007388030 @default.
• W2023403785 creator A5031245175 @default.
• W2023403785 creator A5047996304 @default.
• W2023403785 creator A5058613114 @default.
• W2023403785 date "1998-01-30" @default.
• W2023403785 modified "2023-10-03" @default.
• W2023403785 title "In vitro regulation of pericellular proteolysis in prostatic tumor cells treated with bombesin" @default.
• W2023403785 cites W1482750006 @default.
• W2023403785 cites W1487780734 @default.
• W2023403785 cites W1499469957 @default.
• W2023403785 cites W1520920325 @default.
• W2023403785 cites W1608138774 @default.
• W2023403785 cites W1966553997 @default.
• W2023403785 cites W1983792141 @default.
• W2023403785 cites W1989013514 @default.
• W2023403785 cites W2000197784 @default.
• W2023403785 cites W2008106678 @default.
• W2023403785 cites W2014086967 @default.
• W2023403785 cites W2017903463 @default.
• W2023403785 cites W2042502127 @default.
• W2023403785 cites W2054425455 @default.
• W2023403785 cites W2064430849 @default.
• W2023403785 cites W2079486536 @default.
• W2023403785 cites W2083070422 @default.
• W2023403785 cites W2088738897 @default.
• W2023403785 cites W2107601371 @default.
• W2023403785 cites W2116608163 @default.
• W2023403785 cites W2125311110 @default.
• W2023403785 cites W2145539666 @default.
• W2023403785 cites W2154671319 @default.
• W2023403785 cites W2395111376 @default.
• W2023403785 cites W2417465467 @default.
• W2023403785 doi "https://doi.org/10.1002/(sici)1097-0215(19980130)75:3<418::aid-ijc16>3.0.co;2-4" @default.
• W2023403785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9455804" @default.
• W2023403785 hasPublicationYear "1998" @default.
• W2023403785 type Work @default.
• W2023403785 sameAs 2023403785 @default.
• W2023403785 citedByCount "58" @default.
• W2023403785 countsByYear W20234037852012 @default.
• W2023403785 countsByYear W20234037852013 @default.
• W2023403785 countsByYear W20234037852014 @default.
• W2023403785 countsByYear W20234037852015 @default.
• W2023403785 countsByYear W20234037852018 @default.
• W2023403785 countsByYear W20234037852021 @default.
• W2023403785 countsByYear W20234037852022 @default.
• W2023403785 crossrefType "journal-article" @default.
• W2023403785 hasAuthorship W2023403785A5002876711 @default.
• W2023403785 hasAuthorship W2023403785A5003696637 @default.
• W2023403785 hasAuthorship W2023403785A5007388030 @default.
• W2023403785 hasAuthorship W2023403785A5031245175 @default.
• W2023403785 hasAuthorship W2023403785A5047996304 @default.
• W2023403785 hasAuthorship W2023403785A5058613114 @default.
• W2023403785 hasBestOaLocation W20234037851 @default.
• W2023403785 hasConcept C118303440 @default.
• W2023403785 hasConcept C121608353 @default.
• W2023403785 hasConcept C128240485 @default.
• W2023403785 hasConcept C134018914 @default.
• W2023403785 hasConcept C170493617 @default.
• W2023403785 hasConcept C181199279 @default.
• W2023403785 hasConcept C185592680 @default.
• W2023403785 hasConcept C2776438761 @default.
• W2023403785 hasConcept C2778448772 @default.
• W2023403785 hasConcept C2779679481 @default.
• W2023403785 hasConcept C2779723316 @default.
• W2023403785 hasConcept C2781071845 @default.
• W2023403785 hasConcept C2781307694 @default.
• W2023403785 hasConcept C49039625 @default.
• W2023403785 hasConcept C54355233 @default.
• W2023403785 hasConcept C55493867 @default.
• W2023403785 hasConcept C62112901 @default.
• W2023403785 hasConcept C81885089 @default.
• W2023403785 hasConcept C86803240 @default.
• W2023403785 hasConcept C95444343 @default.
• W2023403785 hasConcept C96232424 @default.
• W2023403785 hasConceptScore W2023403785C118303440 @default.
• W2023403785 hasConceptScore W2023403785C121608353 @default.
• W2023403785 hasConceptScore W2023403785C128240485 @default.
• W2023403785 hasConceptScore W2023403785C134018914 @default.
• W2023403785 hasConceptScore W2023403785C170493617 @default.
• W2023403785 hasConceptScore W2023403785C181199279 @default.
• W2023403785 hasConceptScore W2023403785C185592680 @default.
• W2023403785 hasConceptScore W2023403785C2776438761 @default.
• W2023403785 hasConceptScore W2023403785C2778448772 @default.
• W2023403785 hasConceptScore W2023403785C2779679481 @default.
• W2023403785 hasConceptScore W2023403785C2779723316 @default.
• W2023403785 hasConceptScore W2023403785C2781071845 @default.
• W2023403785 hasConceptScore W2023403785C2781307694 @default.
• W2023403785 hasConceptScore W2023403785C49039625 @default.
• W2023403785 hasConceptScore W2023403785C54355233 @default.
• W2023403785 hasConceptScore W2023403785C55493867 @default.
• W2023403785 hasConceptScore W2023403785C62112901 @default.
• W2023403785 hasConceptScore W2023403785C81885089 @default.
• W2023403785 hasConceptScore W2023403785C86803240 @default.
• W2023403785 hasConceptScore W2023403785C95444343 @default.

• next