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• W2023405860 abstract "A series of polyhalo isophthalonitrile derivatives ( 3 and 4 ) that incorporate a variety of substituents at the 2-, 4-, 5- and/or 6-positions of the isophthalonitrile moieties have been designed and synthesized. These derivatives were evaluated for their antimicrobial activity against Staphylococcus aureus , Bacillus cereus (Gram-positive bacteria), Escherichia coli , Pseudomonas aeruginosa (Gram-negative bacteria); and Candida albicans (Fungi). Compounds 3 and 4 showed stronger inhibition of Gram-positive bacteria and fungi growth, and the antimicrobial ability of compound 3j (a 4-(benzylamino)-5-chloro-2,6-difluoro analog, MIC[SA] = 0.5 μg/mL; MIC[BC] = 0.4 μg/mL; MIC[CA] = 0.5 μg/mL) were close to nofloxacin and fluconazole and identified as the most potent antimicrobial agents in the series. The preliminary analysis of structure–activity relationships is also discussed." @default.
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• W2023405860 date "2013-04-01" @default.
• W2023405860 modified "2023-10-14" @default.
• W2023405860 title "Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives" @default.
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• W2023405860 doi "https://doi.org/10.1016/j.bmcl.2013.02.033" @default.
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