FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023407559> ?p ?o ?g. }

• W2023407559 endingPage "1355" @default.
• W2023407559 startingPage "1344" @default.
• W2023407559 abstract "Background The hypothesis that mechanical stress during reperfusion produces myocyte oncosis and inhibits apoptosis was tested in the present study. Methods and Results Isolated and perfused rat hearts were subjected to 30 min ischemia followed by 150 min reperfusion. In the control-reperfusion heart, the form of myocyte death was a mixture of apoptosis only, oncosis only, and both apoptosis and oncosis. Apoptotic myocytes contained mitochondria that maintained membrane potential (Δψm), whereas oncotic myocytes contained only Δψm-collapsed mitochondria. Treatment with the contractile blocker 2,3-butanedione monoxime (BDM) during reperfusion increased caspase-3 activity and produced predominantly apoptosis. However, withdrawal of BDM provoked oncosis in terminal deoxynucleotide nick-end labeling (TUNEL)-positive myocytes. Myocardial stretch by inflating an intraventricular balloon at the time of reperfusion with BDM increased only oncotic myocytes, whereas the same mechanical stress 120 min after reperfusion increased oncotic myocytes positive for TUNEL. Increased mechanical stress at the time of reperfusion by treatment with isoproterenol or hyposmotic buffer inhibited caspase-3 activity and increased only oncotic myocytes. Co-treatment with the caspase-3 inhibitor, Ac-DEVD-CHO, and BDM during reperfusion inhibited myocyte apoptosis and oncosis but did not inhibit oncosis after withdrawal of BDM. Conclusions These results suggest that mechanical stress is a critical determinant of the form of myocyte death during the early phase of reperfusion. (Circ J 2006; 70: 1344 - 1355)" @default.
• W2023407559 created "2016-06-24" @default.
• W2023407559 creator A5002261228 @default.
• W2023407559 creator A5007020430 @default.
• W2023407559 creator A5022448594 @default.
• W2023407559 creator A5023481013 @default.
• W2023407559 creator A5024333107 @default.
• W2023407559 creator A5029079573 @default.
• W2023407559 creator A5036495006 @default.
• W2023407559 creator A5049314031 @default.
• W2023407559 creator A5059982201 @default.
• W2023407559 creator A5086468895 @default.
• W2023407559 date "2006-01-01" @default.
• W2023407559 modified "2023-10-17" @default.
• W2023407559 title "Role of Mechanical Stress in the Form of Cardiomyocyte Death During the Early Phase of Reperfusion" @default.
• W2023407559 cites W1570908300 @default.
• W2023407559 cites W1575464362 @default.
• W2023407559 cites W1662846808 @default.
• W2023407559 cites W1839071809 @default.
• W2023407559 cites W1969191514 @default.
• W2023407559 cites W1976680355 @default.
• W2023407559 cites W1978581757 @default.
• W2023407559 cites W1990767395 @default.
• W2023407559 cites W2029691673 @default.
• W2023407559 cites W2037621841 @default.
• W2023407559 cites W2046848104 @default.
• W2023407559 cites W2055545648 @default.
• W2023407559 cites W2068048197 @default.
• W2023407559 cites W2069679581 @default.
• W2023407559 cites W2070839419 @default.
• W2023407559 cites W2070951720 @default.
• W2023407559 cites W2076192570 @default.
• W2023407559 cites W2083548112 @default.
• W2023407559 cites W2089663038 @default.
• W2023407559 cites W2091209297 @default.
• W2023407559 cites W2107087092 @default.
• W2023407559 cites W2117354575 @default.
• W2023407559 cites W2120278715 @default.
• W2023407559 cites W2124872060 @default.
• W2023407559 cites W2133858793 @default.
• W2023407559 cites W2135325091 @default.
• W2023407559 cites W2151501496 @default.
• W2023407559 cites W2164507878 @default.
• W2023407559 cites W2177849387 @default.
• W2023407559 doi "https://doi.org/10.1253/circj.70.1344" @default.
• W2023407559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16998271" @default.
• W2023407559 hasPublicationYear "2006" @default.
• W2023407559 type Work @default.
• W2023407559 sameAs 2023407559 @default.
• W2023407559 citedByCount "25" @default.
• W2023407559 countsByYear W20234075592012 @default.
• W2023407559 countsByYear W20234075592013 @default.
• W2023407559 countsByYear W20234075592014 @default.
• W2023407559 countsByYear W20234075592021 @default.
• W2023407559 crossrefType "journal-article" @default.
• W2023407559 hasAuthorship W2023407559A5002261228 @default.
• W2023407559 hasAuthorship W2023407559A5007020430 @default.
• W2023407559 hasAuthorship W2023407559A5022448594 @default.
• W2023407559 hasAuthorship W2023407559A5023481013 @default.
• W2023407559 hasAuthorship W2023407559A5024333107 @default.
• W2023407559 hasAuthorship W2023407559A5029079573 @default.
• W2023407559 hasAuthorship W2023407559A5036495006 @default.
• W2023407559 hasAuthorship W2023407559A5049314031 @default.
• W2023407559 hasAuthorship W2023407559A5059982201 @default.
• W2023407559 hasAuthorship W2023407559A5086468895 @default.
• W2023407559 hasBestOaLocation W20234075591 @default.
• W2023407559 hasConcept C104317684 @default.
• W2023407559 hasConcept C126322002 @default.
• W2023407559 hasConcept C134018914 @default.
• W2023407559 hasConcept C168529131 @default.
• W2023407559 hasConcept C185592680 @default.
• W2023407559 hasConcept C190283241 @default.
• W2023407559 hasConcept C196795494 @default.
• W2023407559 hasConcept C207200792 @default.
• W2023407559 hasConcept C31573885 @default.
• W2023407559 hasConcept C541997718 @default.
• W2023407559 hasConcept C55493867 @default.
• W2023407559 hasConcept C71924100 @default.
• W2023407559 hasConcept C86803240 @default.
• W2023407559 hasConcept C95444343 @default.
• W2023407559 hasConceptScore W2023407559C104317684 @default.
• W2023407559 hasConceptScore W2023407559C126322002 @default.
• W2023407559 hasConceptScore W2023407559C134018914 @default.
• W2023407559 hasConceptScore W2023407559C168529131 @default.
• W2023407559 hasConceptScore W2023407559C185592680 @default.
• W2023407559 hasConceptScore W2023407559C190283241 @default.
• W2023407559 hasConceptScore W2023407559C196795494 @default.
• W2023407559 hasConceptScore W2023407559C207200792 @default.
• W2023407559 hasConceptScore W2023407559C31573885 @default.
• W2023407559 hasConceptScore W2023407559C541997718 @default.
• W2023407559 hasConceptScore W2023407559C55493867 @default.
• W2023407559 hasConceptScore W2023407559C71924100 @default.
• W2023407559 hasConceptScore W2023407559C86803240 @default.
• W2023407559 hasConceptScore W2023407559C95444343 @default.
• W2023407559 hasIssue "10" @default.
• W2023407559 hasLocation W20234075591 @default.
• W2023407559 hasLocation W20234075592 @default.
• W2023407559 hasOpenAccess W2023407559 @default.

• next