FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023408434> ?p ?o ?g. }

• W2023408434 abstract "There has been increasing interest in the use of metformin and vitamin D to reduce cancer risk and improve outcomes. Metformin, an oral antidiabetic drug, improves insulin resistance and has been associated with reduced cancer incidence and cancer mortality. Low levels of vitamin D have also been associated with increased cancer risk, mainly in retrospective studies, and it has been suggested that vitamin D supplementation might play a role in cancer prevention. Preclinical data provide a biologic rationale for these associations; however, the human data arise predominantly from observational studies and caution is needed in their translation into clinical practice. This is because of the recognized limitations of observational studies, such as time-related survival biases, selection and referral biases, short follow-up, and the presence of confounding factors that can lead to spurious or inaccurate findings. Combined examination of associations with cancer risk and outcome (occurring when exposure in a population that does not yet have cancer is analyzed in relation to cancer death) may yield results that are difficult to interpret. Finally, associations across all cancers may differ from those in specific cancer types. These shortcomings can be overcome in properly designed and adequately powered prospective randomized trials; however, such trials are both expensive and time consuming. We review the literature examining the associations of metformin and vitamin D with cancer, discussing weakness and strengths and making recommendations for further research and clinical practice." @default.
• W2023408434 created "2016-06-24" @default.
• W2023408434 creator A5003825543 @default.
• W2023408434 creator A5059321337 @default.
• W2023408434 date "2014-05-01" @default.
• W2023408434 modified "2023-10-16" @default.
• W2023408434 title "Hype versus Hope: Metformin and Vitamin D as Anticancer Agents" @default.
• W2023408434 cites W1572187257 @default.
• W2023408434 cites W1965830162 @default.
• W2023408434 cites W1987041848 @default.
• W2023408434 cites W1994394721 @default.
• W2023408434 cites W1997303839 @default.
• W2023408434 cites W1998243074 @default.
• W2023408434 cites W2010450183 @default.
• W2023408434 cites W2011053969 @default.
• W2023408434 cites W2030500737 @default.
• W2023408434 cites W2040051569 @default.
• W2023408434 cites W2080975831 @default.
• W2023408434 cites W2081540191 @default.
• W2023408434 cites W2089959409 @default.
• W2023408434 cites W2095695954 @default.
• W2023408434 cites W2096150705 @default.
• W2023408434 cites W2096572264 @default.
• W2023408434 cites W2099607844 @default.
• W2023408434 cites W2116841061 @default.
• W2023408434 cites W2117392117 @default.
• W2023408434 cites W2123346488 @default.
• W2023408434 cites W2129620555 @default.
• W2023408434 cites W2134267892 @default.
• W2023408434 cites W2134890163 @default.
• W2023408434 cites W2140164776 @default.
• W2023408434 cites W2146511561 @default.
• W2023408434 cites W2154557465 @default.
• W2023408434 cites W2171998898 @default.
• W2023408434 cites W2320070551 @default.
• W2023408434 doi "https://doi.org/10.14694/edbook_am.2014.34.e69" @default.
• W2023408434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24857149" @default.
• W2023408434 hasPublicationYear "2014" @default.
• W2023408434 type Work @default.
• W2023408434 sameAs 2023408434 @default.
• W2023408434 citedByCount "3" @default.
• W2023408434 countsByYear W20234084342014 @default.
• W2023408434 countsByYear W20234084342015 @default.
• W2023408434 crossrefType "journal-article" @default.
• W2023408434 hasAuthorship W2023408434A5003825543 @default.
• W2023408434 hasAuthorship W2023408434A5059321337 @default.
• W2023408434 hasConcept C121608353 @default.
• W2023408434 hasConcept C126322002 @default.
• W2023408434 hasConcept C143998085 @default.
• W2023408434 hasConcept C177713679 @default.
• W2023408434 hasConcept C23131810 @default.
• W2023408434 hasConcept C2779306644 @default.
• W2023408434 hasConcept C2780323712 @default.
• W2023408434 hasConcept C2908647359 @default.
• W2023408434 hasConcept C535046627 @default.
• W2023408434 hasConcept C71924100 @default.
• W2023408434 hasConcept C77350462 @default.
• W2023408434 hasConcept C99454951 @default.
• W2023408434 hasConceptScore W2023408434C121608353 @default.
• W2023408434 hasConceptScore W2023408434C126322002 @default.
• W2023408434 hasConceptScore W2023408434C143998085 @default.
• W2023408434 hasConceptScore W2023408434C177713679 @default.
• W2023408434 hasConceptScore W2023408434C23131810 @default.
• W2023408434 hasConceptScore W2023408434C2779306644 @default.
• W2023408434 hasConceptScore W2023408434C2780323712 @default.
• W2023408434 hasConceptScore W2023408434C2908647359 @default.
• W2023408434 hasConceptScore W2023408434C535046627 @default.
• W2023408434 hasConceptScore W2023408434C71924100 @default.
• W2023408434 hasConceptScore W2023408434C77350462 @default.
• W2023408434 hasConceptScore W2023408434C99454951 @default.
• W2023408434 hasLocation W20234084341 @default.
• W2023408434 hasLocation W20234084342 @default.
• W2023408434 hasOpenAccess W2023408434 @default.
• W2023408434 hasPrimaryLocation W20234084341 @default.
• W2023408434 hasRelatedWork W1975046232 @default.
• W2023408434 hasRelatedWork W2059086208 @default.
• W2023408434 hasRelatedWork W2090141858 @default.
• W2023408434 hasRelatedWork W2261720738 @default.
• W2023408434 hasRelatedWork W2295590918 @default.
• W2023408434 hasRelatedWork W2561095322 @default.
• W2023408434 hasRelatedWork W2597257596 @default.
• W2023408434 hasRelatedWork W2899084033 @default.
• W2023408434 hasRelatedWork W3199624450 @default.
• W2023408434 hasRelatedWork W4237910324 @default.
• W2023408434 isParatext "false" @default.
• W2023408434 isRetracted "false" @default.
• W2023408434 magId "2023408434" @default.
• W2023408434 workType "article" @default.