FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023409525> ?p ?o ?g. }

• W2023409525 abstract "We mapped the quantitative trait loci (QTL) that contribute to the robust difference in maximal electroshock seizure threshold (MEST) between C57BLKS/J (BKS) and C57BL10S/J (B10S) mice. BKS, B10S, BKS × B10S F1 and BKS × B10S F2 intercross mice were tested for MEST at 8-9 weeks of age. Results of F2 testing showed that, in this cross, MEST is a continuously distributed trait determined by polygenic inheritance. Mice from the extremes of the trait distribution were genotyped using microarray technology. MEST correlated significantly with body weight and sex; however, because of the high correlation between these factors, the QTL mapping was conditioned on sex alone. A sequential series of statistical analyses was used to map QTLs including single-point, multipoint and multilocus methods. Two QTLs reached genome-wide levels of significance based upon an empirically determined permutation threshold: chromosome 6 (LOD = 6.0 at ∼69 cM) and chromosome 8 (LOD = 5.7 at ∼27 cM). Two additional QTLs were retained in a multilocus regression model: chromosome 3 (LOD = 2.1 at ∼68 cM) and chromosome 5 (LOD = 2.7 at ∼73 cM). Together the four QTLs explain one third of the total phenotypic variance in the mapping population. Lack of overlap between the major MEST QTLs mapped here in BKS and B10S mice and those mapped previously in C57BL/6J and DBA/2J mice (strains that are closely related to BKS and B10S) suggest that BKS and B10S represent a new polygenic mouse model for investigating susceptibility to seizures." @default.
• W2023409525 created "2016-06-24" @default.
• W2023409525 creator A5012998944 @default.
• W2023409525 creator A5015320644 @default.
• W2023409525 creator A5016371872 @default.
• W2023409525 creator A5025114043 @default.
• W2023409525 creator A5027547141 @default.
• W2023409525 creator A5040285293 @default.
• W2023409525 creator A5048653843 @default.
• W2023409525 creator A5074828414 @default.
• W2023409525 creator A5083779488 @default.
• W2023409525 creator A5089957785 @default.
• W2023409525 creator A5090139384 @default.
• W2023409525 creator A5091613154 @default.
• W2023409525 date "2010-12-22" @default.
• W2023409525 modified "2023-09-23" @default.
• W2023409525 title "Quantitative trait loci for electrical seizure threshold mapped in C57BLKS/J and C57BL/10SnJ mice" @default.
• W2023409525 cites W150986708 @default.
• W2023409525 cites W1922602437 @default.
• W2023409525 cites W1937687163 @default.
• W2023409525 cites W1980584574 @default.
• W2023409525 cites W1991641846 @default.
• W2023409525 cites W2000523742 @default.
• W2023409525 cites W2002353847 @default.
• W2023409525 cites W2014751410 @default.
• W2023409525 cites W2026301332 @default.
• W2023409525 cites W2028565747 @default.
• W2023409525 cites W2058262566 @default.
• W2023409525 cites W2059851961 @default.
• W2023409525 cites W2061201047 @default.
• W2023409525 cites W2067658528 @default.
• W2023409525 cites W2068013244 @default.
• W2023409525 cites W2072151819 @default.
• W2023409525 cites W2079073564 @default.
• W2023409525 cites W2083462786 @default.
• W2023409525 cites W2085880679 @default.
• W2023409525 cites W2089075373 @default.
• W2023409525 cites W2095000729 @default.
• W2023409525 cites W2103090173 @default.
• W2023409525 cites W2113748834 @default.
• W2023409525 cites W2116053845 @default.
• W2023409525 cites W2117007075 @default.
• W2023409525 cites W2124553708 @default.
• W2023409525 cites W2128465587 @default.
• W2023409525 cites W2134705056 @default.
• W2023409525 cites W2158846949 @default.
• W2023409525 cites W2188778181 @default.
• W2023409525 cites W2305659333 @default.
• W2023409525 doi "https://doi.org/10.1111/j.1601-183x.2010.00668.x" @default.
• W2023409525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21129161" @default.
• W2023409525 hasPublicationYear "2010" @default.
• W2023409525 type Work @default.
• W2023409525 sameAs 2023409525 @default.
• W2023409525 citedByCount "6" @default.
• W2023409525 countsByYear W20234095252012 @default.
• W2023409525 countsByYear W20234095252014 @default.
• W2023409525 crossrefType "journal-article" @default.
• W2023409525 hasAuthorship W2023409525A5012998944 @default.
• W2023409525 hasAuthorship W2023409525A5015320644 @default.
• W2023409525 hasAuthorship W2023409525A5016371872 @default.
• W2023409525 hasAuthorship W2023409525A5025114043 @default.
• W2023409525 hasAuthorship W2023409525A5027547141 @default.
• W2023409525 hasAuthorship W2023409525A5040285293 @default.
• W2023409525 hasAuthorship W2023409525A5048653843 @default.
• W2023409525 hasAuthorship W2023409525A5074828414 @default.
• W2023409525 hasAuthorship W2023409525A5083779488 @default.
• W2023409525 hasAuthorship W2023409525A5089957785 @default.
• W2023409525 hasAuthorship W2023409525A5090139384 @default.
• W2023409525 hasAuthorship W2023409525A5091613154 @default.
• W2023409525 hasBestOaLocation W20234095251 @default.
• W2023409525 hasConcept C104317684 @default.
• W2023409525 hasConcept C105795698 @default.
• W2023409525 hasConcept C106934330 @default.
• W2023409525 hasConcept C199360897 @default.
• W2023409525 hasConcept C202632270 @default.
• W2023409525 hasConcept C2908647359 @default.
• W2023409525 hasConcept C30481170 @default.
• W2023409525 hasConcept C33923547 @default.
• W2023409525 hasConcept C41008148 @default.
• W2023409525 hasConcept C54355233 @default.
• W2023409525 hasConcept C71924100 @default.
• W2023409525 hasConcept C81941488 @default.
• W2023409525 hasConcept C86803240 @default.
• W2023409525 hasConcept C99454951 @default.
• W2023409525 hasConceptScore W2023409525C104317684 @default.
• W2023409525 hasConceptScore W2023409525C105795698 @default.
• W2023409525 hasConceptScore W2023409525C106934330 @default.
• W2023409525 hasConceptScore W2023409525C199360897 @default.
• W2023409525 hasConceptScore W2023409525C202632270 @default.
• W2023409525 hasConceptScore W2023409525C2908647359 @default.
• W2023409525 hasConceptScore W2023409525C30481170 @default.
• W2023409525 hasConceptScore W2023409525C33923547 @default.
• W2023409525 hasConceptScore W2023409525C41008148 @default.
• W2023409525 hasConceptScore W2023409525C54355233 @default.
• W2023409525 hasConceptScore W2023409525C71924100 @default.
• W2023409525 hasConceptScore W2023409525C81941488 @default.
• W2023409525 hasConceptScore W2023409525C86803240 @default.
• W2023409525 hasConceptScore W2023409525C99454951 @default.
• W2023409525 hasLocation W20234095251 @default.
• W2023409525 hasLocation W20234095252 @default.

• next