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- W2023411214 abstract "A new class of pyridobenzophenoxazine compounds has been developed as topoisomerase II inhibitors for anticancer chemotherapy. These compounds were designed based on a proposed model of a quinobenzoxazine self-assembly complex on DNA. They showed excellent inhibitory effects on several tumor cell lines with nanomolar IC50 values. Their cytotoxic potency correlates with their ability to unwind DNA and inhibit topoisomerase II." @default.
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- W2023411214 date "1998-10-22" @default.
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- W2023411214 title "Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model." @default.
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- W2023411214 doi "https://doi.org/10.1021/jm980265c" @default.
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