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- W2023411933 abstract "Background— Remodeling of the mitral annulus contributes to progression of mitral regurgitation (MR). In patients with moderate-to-severe MR, short-term treatment with β-blockers has been shown to increase left ventricular (LV) end-diastolic and end-systolic volume, and this could deleteriously increase mitral valve annular dimensions. The objective of this study was to quantify the effects of a short duration of β-blocker treatment on mitral annular dimensions and dynamics in patients with MR due to primary degenerative valve disease. Methods and Results— Twenty-five patients with moderate-to-severe degenerative MR and normal LV systolic function were studied in a double-blind crossover experiment using a β1-selective adrenergic blocker and placebo administered for 14±3 days. Cardiac MRI images were acquired after each treatment period to quantify mitral annular dimensions. At end diastole, there was no change in annular area (1659±331 versus 1632±299 mm 2 ; P <0.19), annular perimeter (154.3±16.4 versus 152±13.9 mm; P <0.13), septal-lateral (SL) dimension (38.0±5 versus 39.0±4.5 mm; P <0.15), or annular height (9.8±3.8 versus 9.5±2.5 mm; P <0.53). β-blockade resulted in significant end-diastole decreases in commissure-commissure dimension (48.9±4.6 versus 47.2±4.0 mm; P <0.01) and eccentricity (1.3±0.2 versus 1.2±0.1; P <0.01). At end systole (ES), β-blockade conferred a small, but significant decrease in annular perimeter (161.0±19.3 versus 156.8±16.9 mm; P <0.04) and eccentricity (1.2±0.1 versus 1.1±0.1; P <0.02), and the SL dimension significantly increased (41.5±5.7 versus 43.0±5.3 mm; P <0.03). Commissure-commissure dimension, annular area, and annular height at ES were not significantly different. Conclusions— Despite significant increases in LV end-diastolic and end-systolic volume, short-term β-blocker treatment of patients with moderate-to-severe MR reduced or preserved all mitral annular dimensions except SL at ES." @default.
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- W2023411933 date "2010-11-01" @default.
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- W2023411933 title "Changes in Mitral Annular Geometry and Dynamics With β-Blockade in Patients With Degenerative Mitral Valve Disease" @default.
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- W2023411933 doi "https://doi.org/10.1161/circimaging.110.959171" @default.
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