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- W2023428059 abstract "The neuromuscular blocking effects of (+)- and (-)-amphetamine were evaluated for possible actions via the adrenergic and cholinergic systems employing the isolated rat phrenic-nerve diaphragm preparation. Dopaminergic and α- and β-adrenergic receptor blockers failed to modify the blocking effects of amphetamine on nerve-stimulated diaphragms suggesting the absence of catecholaminergic involvement. In chronically denervated diaphragms, amphetamine (2.7–4.05 × 10 −4 M) and the non-depolarizing blocker (+)-tubocurarine (10 −7 M) shifted the acetylcholine concentration-response curve to the right and failed to produce muscle contracture; the latter effect was produced by the depolarizing blocker succinylcholine (10 −5 M). Physostigmine (1(10 −5 M) and KCl (11mM) reversed amphetamine (5.4 × 10 −4 M) and tubocurarine (5 × 10 −7 M) blockade, but not that elicited by succinylcholine (10 −5 M). Tetanus and post-tetanic potentiation were depressed in a concentration-dependent manner by the amphetamine isomers, with the (+)-isomer 1.8 times more potent than its (-)-enantiomer. These results indicate that amphetamine exhibits post-synaptic neuromuscular inhibition resembling curare-like nondepolarizing blockade, and that (+) -amphetamine is more potent as a neuromuscular blocker than its (-)-isomer." @default.
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- W2023428059 title "Curare-like effects of the amphetamine isomers on neuromuscular transmission" @default.
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- W2023428059 doi "https://doi.org/10.1016/0028-3908(78)90111-9" @default.
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