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• W2023429500 abstract "Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters (“pseudo-diffusion” coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain’s microvasculature." @default.
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• W2023429500 date "2013-08-30" @default.
• W2023429500 modified "2023-10-16" @default.
• W2023429500 title "Dependence of Brain Intravoxel Incoherent Motion Perfusion Parameters on the Cardiac Cycle" @default.
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• W2023429500 doi "https://doi.org/10.1371/journal.pone.0072856" @default.
• W2023429500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3758329" @default.
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