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• W2023429580 abstract "Calcitriol, the bioactive metabolite of vitamin D, was reported to inhibit HCV production in a synergistic fashion with interferon, a treatment in vitro. Our previous study established that miR-130a inhibits HCV replication by restoring the host innate immune response. We aimed to determine whether there is additive inhibitory effect of calcitriol and miR-130a on HCV replication. Here we showed that calcitriol potentiates the anti-HCV effect of miR-130a in both Con1b replicon and J6/JFH1 culture systems. Intriguingly, this potentiating effect of calcitriol on miR-130a was not through upregulating the expression of cellular miR-130a or through increasing the miR-130a-mediated IFNα/β production. All these findings may contribute to the development of novel anti-HCV therapeutic strategies although the antiviral mechanism needs to be further investigated." @default.
• W2023429580 created "2016-06-24" @default.
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• W2023429580 date "2015-01-01" @default.
• W2023429580 modified "2023-09-28" @default.
• W2023429580 title "Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway" @default.
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• W2023429580 doi "https://doi.org/10.1155/2015/508989" @default.
• W2023429580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4427768" @default.
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