FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023431275> ?p ?o ?g. }

• W2023431275 endingPage "271" @default.
• W2023431275 startingPage "255" @default.
• W2023431275 abstract "Previous studies have described the distribution of melanin-concentrating hormone (MCH) and neuropeptide EI (NEI) in the rat central nervous system (CNS), and revealed this peptidergic system to be primarily localized in neurons within the lateral hypothalamic area (LHA) and zona incerta (ZI). Moreover, an extensive MCH- and NEI-immunoreactive (ir) fiber distribution has been described throughout the CNS, including a dense innervation within the periaqueductal gray matter (PAG). MCH and NEI have become important markers for the LHA, which harbors a variety of neuronal types as well as the medial forebrain bundle, a complex system of fibers which extends rostrocaudally throughout this area. In the present study, the projection patterns of MCH- and NEI-ir fibers within the PAG were characterized using a diamino benzidine immunoperoxidase procedure to localize each of these peptides in normal rat brain sections. MCH- and NEI-ir fibers were seen coursing through all of its subdivisions the entire length of the PAG, with a more condensed number of fibers in the periaqueductal medial zone. The primary origin(s) of these PAG afferents were determined in combined retrograde tracing immunofluorescent studies in which true blue (TB) was injected into various subdivisions of the PAG. TB-filled MCH-ir neurons were identified mainly in the rostral portion of the medial ZI (ZIm) and in the tuberal LHA (LHAt). Studies confirming this MCH-ir projection in which anterograde tracer (Phaseolus vulgaris leucoagglutinin) was injected into various regions in and around the LHA and ZI revealed a distinction in the PAG projections arising from these nuclei. ZIm injections resulted in labeled fibers mainly within the rostral dorsomedial and dorsolateral regions of the PAG, whereas injections in the LHAt revealed an innervation at intermediate and caudal levels in the ventrolateral region. Since the MCH and NEI fiber distribution patterns in the PAG are identical, this would suggest that these peptides are colocalized within the hypothalamus. Sequential immunofluorescent staining for MCH and NEI on tissue from rats who had received TB injections into the PAG confirmed this, and revealed that approximately 15% of all tracer-filled neurons in the LHA and ZI were both MCH- and NEI-ir. In fact, the vast majority of MCH-ir neurons within these regions also colocalize with NEI. Therefore, the MCH/NEI projection patterns within the PAG arise from two major sources: the ZIm which supplies afferents via a medial pathway that enters the PAG dorsally at rostral levels, and a pathway originating in the LHA that enters the PAG ventrally at more caudal levels. The ZIm and LHA are believed to be the primary, if not the only, sources of MCH and NEI projections to the PAG." @default.
• W2023431275 created "2016-06-24" @default.
• W2023431275 creator A5081479185 @default.
• W2023431275 creator A5091177547 @default.
• W2023431275 date "1997-05-01" @default.
• W2023431275 modified "2023-10-11" @default.
• W2023431275 title "Study of the origins of melanin-concentrating hormone and neuropeptide EI immunoreactive projections to the periaqueductal gray matter" @default.
• W2023431275 cites W120687995 @default.
• W2023431275 cites W1469514838 @default.
• W2023431275 cites W1863617761 @default.
• W2023431275 cites W195879350 @default.
• W2023431275 cites W1967318820 @default.
• W2023431275 cites W1978082185 @default.
• W2023431275 cites W1979127822 @default.
• W2023431275 cites W1980021607 @default.
• W2023431275 cites W1983511521 @default.
• W2023431275 cites W1985903673 @default.
• W2023431275 cites W1986845109 @default.
• W2023431275 cites W1987551840 @default.
• W2023431275 cites W1988107620 @default.
• W2023431275 cites W1991256932 @default.
• W2023431275 cites W1993137505 @default.
• W2023431275 cites W1994360459 @default.
• W2023431275 cites W1998664936 @default.
• W2023431275 cites W1999555200 @default.
• W2023431275 cites W2000754051 @default.
• W2023431275 cites W2004917303 @default.
• W2023431275 cites W2006547733 @default.
• W2023431275 cites W2008303605 @default.
• W2023431275 cites W2016821300 @default.
• W2023431275 cites W2024428069 @default.
• W2023431275 cites W2028618631 @default.
• W2023431275 cites W2032304198 @default.
• W2023431275 cites W2039701928 @default.
• W2023431275 cites W2044751017 @default.
• W2023431275 cites W2047968968 @default.
• W2023431275 cites W2051405630 @default.
• W2023431275 cites W2052291525 @default.
• W2023431275 cites W2059033731 @default.
• W2023431275 cites W2062360803 @default.
• W2023431275 cites W2067039618 @default.
• W2023431275 cites W2073148375 @default.
• W2023431275 cites W2075256367 @default.
• W2023431275 cites W2081248007 @default.
• W2023431275 cites W2082718544 @default.
• W2023431275 cites W2092115378 @default.
• W2023431275 cites W2118507406 @default.
• W2023431275 cites W2149933139 @default.
• W2023431275 cites W2158649743 @default.
• W2023431275 cites W2179304656 @default.
• W2023431275 cites W2185216683 @default.
• W2023431275 cites W299596264 @default.
• W2023431275 cites W322867770 @default.
• W2023431275 cites W66138198 @default.
• W2023431275 cites W69412436 @default.
• W2023431275 cites W963227066 @default.
• W2023431275 doi "https://doi.org/10.1016/s0006-8993(97)00104-2" @default.
• W2023431275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9175893" @default.
• W2023431275 hasPublicationYear "1997" @default.
• W2023431275 type Work @default.
• W2023431275 sameAs 2023431275 @default.
• W2023431275 citedByCount "49" @default.
• W2023431275 countsByYear W20234312752013 @default.
• W2023431275 countsByYear W20234312752014 @default.
• W2023431275 countsByYear W20234312752015 @default.
• W2023431275 countsByYear W20234312752016 @default.
• W2023431275 countsByYear W20234312752017 @default.
• W2023431275 countsByYear W20234312752018 @default.
• W2023431275 countsByYear W20234312752019 @default.
• W2023431275 countsByYear W20234312752020 @default.
• W2023431275 crossrefType "journal-article" @default.
• W2023431275 hasAuthorship W2023431275A5081479185 @default.
• W2023431275 hasAuthorship W2023431275A5091177547 @default.
• W2023431275 hasConcept C105702510 @default.
• W2023431275 hasConcept C118303440 @default.
• W2023431275 hasConcept C169760540 @default.
• W2023431275 hasConcept C170493617 @default.
• W2023431275 hasConcept C2776378061 @default.
• W2023431275 hasConcept C2776632733 @default.
• W2023431275 hasConcept C2776669363 @default.
• W2023431275 hasConcept C2777003273 @default.
• W2023431275 hasConcept C2778474254 @default.
• W2023431275 hasConcept C2779089633 @default.
• W2023431275 hasConcept C2779715522 @default.
• W2023431275 hasConcept C2780062018 @default.
• W2023431275 hasConcept C2781069035 @default.
• W2023431275 hasConcept C513476851 @default.
• W2023431275 hasConcept C529278444 @default.
• W2023431275 hasConcept C552161191 @default.
• W2023431275 hasConcept C55493867 @default.
• W2023431275 hasConcept C86803240 @default.
• W2023431275 hasConceptScore W2023431275C105702510 @default.
• W2023431275 hasConceptScore W2023431275C118303440 @default.
• W2023431275 hasConceptScore W2023431275C169760540 @default.
• W2023431275 hasConceptScore W2023431275C170493617 @default.
• W2023431275 hasConceptScore W2023431275C2776378061 @default.
• W2023431275 hasConceptScore W2023431275C2776632733 @default.
• W2023431275 hasConceptScore W2023431275C2776669363 @default.

• next