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- W2023432887 abstract "Abstract A brief overview is presented of the rapidly evolving effects of thrombin, other serine proteinases, their proteinase‐activated receptors (PARs), and their downstream signaling pathways in the peripheral (PNS) and central nervous system (CNS). In other articles presented in this volume of Drug Development Research , emphasis on the role of thrombin and PARs in astrocyte and microglial function is emphasized and will only be touched upon herein. This overview focuses on the PAR family, principally PAR 1 , in neuronal dysfunction and what appears to be a differential vulnerability to thrombin in neuronal subsets. It also emphasizes upregulation of PARs in neurodegeneration and neurotrauma as part of a neuroplastic response, but which may be maladaptive as well as adaptive in effect. Finally, regulation of PAR signaling will be mentioned—through one or more G‐protein‐coupled receptor regulated protein kinases—as they relate to microglial responses. The role(s) of thrombin and PAR signaling in neuroplasticity is in keeping with emerging roles for these pathways in pathophysiologic responses, and demands a careful evaluation by the pharmacologic community in terms of drug development in the CNS. Drug Dev. Res. 60:58–64, 2003. © 2003 Wiley‐Liss, Inc." @default.
- W2023432887 created "2016-06-24" @default.
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- W2023432887 date "2003-09-01" @default.
- W2023432887 modified "2023-09-23" @default.
- W2023432887 title "Proteinase-activated receptors (PARs) in the nervous system: Roles in neuroplasticity and neurotrauma" @default.
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- W2023432887 doi "https://doi.org/10.1002/ddr.10321" @default.
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