FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023440263> ?p ?o ?g. }

• W2023440263 endingPage "5299" @default.
• W2023440263 startingPage "5291" @default.
• W2023440263 abstract "ABSTRACT The RelA, RelP, and RelQ enzymes are responsible for the production of the alarmone (p)ppGpp in Streptococcus mutans . A strain lacking all three synthetases (Δ relAPQ ) does not grow in minimal medium lacking the branched-chain amino acids (BCAA) leucine or valine but grows well if isoleucine is also omitted. Here, we investigated whether there was a correlation between growth in the absence of leucine and valine with (p)ppGpp pools and the activation of CodY. By using a combination of single, double, and triple mutants lacking the (p)ppGpp synthetase enzymes, we demonstrated that the ability to grow in the absence of leucine or valine required basal levels of (p)ppGpp production by RelP and RelQ. The introduction of a codY mutation into the Δ relAPQ strain fully restored growth in medium lacking leucine or valine, revealing that the growth-defective phenotype of Δ relAPQ was directly linked to CodY. Lowering GTP levels through the addition of decoyinine did not alleviate CodY repression or affect the expression of genes involved in BCAA biosynthesis, suggesting that S. mutans CodY is not activated by GTP. The results of phenotypic studies revealed that the codY mutant had a reduced capacity to form biofilms and that its growth was more sensitive to low pH, showing a role for CodY in two key virulence properties of S. mutans . Microarray results revealed the extent of the CodY regulon. Notably, the identification of putative CodY-binding boxes upstream of genes that were downregulated in the codY mutant indicates that CodY may also function as a transcriptional activator in S. mutans ." @default.
• W2023440263 created "2016-06-24" @default.
• W2023440263 creator A5001524904 @default.
• W2023440263 creator A5004675787 @default.
• W2023440263 creator A5022248956 @default.
• W2023440263 creator A5050732338 @default.
• W2023440263 creator A5089517528 @default.
• W2023440263 date "2008-08-01" @default.
• W2023440263 modified "2023-10-14" @default.
• W2023440263 title "Global Regulation by (p)ppGpp and CodY in <i>Streptococcus mutans</i>" @default.
• W2023440263 cites W1515163878 @default.
• W2023440263 cites W1546932446 @default.
• W2023440263 cites W1550199195 @default.
• W2023440263 cites W1605223633 @default.
• W2023440263 cites W1616230851 @default.
• W2023440263 cites W1809685151 @default.
• W2023440263 cites W1834684906 @default.
• W2023440263 cites W1862107393 @default.
• W2023440263 cites W1963928439 @default.
• W2023440263 cites W1977782657 @default.
• W2023440263 cites W1978747627 @default.
• W2023440263 cites W1980392633 @default.
• W2023440263 cites W1999382865 @default.
• W2023440263 cites W2001826165 @default.
• W2023440263 cites W2002552484 @default.
• W2023440263 cites W2010637767 @default.
• W2023440263 cites W2014429558 @default.
• W2023440263 cites W2014540083 @default.
• W2023440263 cites W2021380881 @default.
• W2023440263 cites W2055114795 @default.
• W2023440263 cites W2069419313 @default.
• W2023440263 cites W2096799663 @default.
• W2023440263 cites W2101835392 @default.
• W2023440263 cites W2103083719 @default.
• W2023440263 cites W2110591870 @default.
• W2023440263 cites W2116984091 @default.
• W2023440263 cites W2118937626 @default.
• W2023440263 cites W2123641345 @default.
• W2023440263 cites W2128146786 @default.
• W2023440263 cites W2128301757 @default.
• W2023440263 cites W2128485286 @default.
• W2023440263 cites W2128618257 @default.
• W2023440263 cites W2130775386 @default.
• W2023440263 cites W2132522708 @default.
• W2023440263 cites W2136739054 @default.
• W2023440263 cites W2145170668 @default.
• W2023440263 cites W2147310463 @default.
• W2023440263 cites W2148556915 @default.
• W2023440263 cites W2149948630 @default.
• W2023440263 cites W2160500822 @default.
• W2023440263 cites W2162822024 @default.
• W2023440263 cites W2165521960 @default.
• W2023440263 doi "https://doi.org/10.1128/jb.00288-08" @default.
• W2023440263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2493251" @default.
• W2023440263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18539745" @default.
• W2023440263 hasPublicationYear "2008" @default.
• W2023440263 type Work @default.
• W2023440263 sameAs 2023440263 @default.
• W2023440263 citedByCount "87" @default.
• W2023440263 countsByYear W20234402632012 @default.
• W2023440263 countsByYear W20234402632013 @default.
• W2023440263 countsByYear W20234402632014 @default.
• W2023440263 countsByYear W20234402632015 @default.
• W2023440263 countsByYear W20234402632016 @default.
• W2023440263 countsByYear W20234402632017 @default.
• W2023440263 countsByYear W20234402632018 @default.
• W2023440263 countsByYear W20234402632019 @default.
• W2023440263 countsByYear W20234402632020 @default.
• W2023440263 countsByYear W20234402632022 @default.
• W2023440263 countsByYear W20234402632023 @default.
• W2023440263 crossrefType "journal-article" @default.
• W2023440263 hasAuthorship W2023440263A5001524904 @default.
• W2023440263 hasAuthorship W2023440263A5004675787 @default.
• W2023440263 hasAuthorship W2023440263A5022248956 @default.
• W2023440263 hasAuthorship W2023440263A5050732338 @default.
• W2023440263 hasAuthorship W2023440263A5089517528 @default.
• W2023440263 hasBestOaLocation W20234402631 @default.
• W2023440263 hasConcept C104317684 @default.
• W2023440263 hasConcept C118716 @default.
• W2023440263 hasConcept C127716648 @default.
• W2023440263 hasConcept C143065580 @default.
• W2023440263 hasConcept C181199279 @default.
• W2023440263 hasConcept C26628138 @default.
• W2023440263 hasConcept C2776580952 @default.
• W2023440263 hasConcept C2777305461 @default.
• W2023440263 hasConcept C2777573094 @default.
• W2023440263 hasConcept C2778430296 @default.
• W2023440263 hasConcept C515207424 @default.
• W2023440263 hasConcept C523546767 @default.
• W2023440263 hasConcept C54355233 @default.
• W2023440263 hasConcept C55493867 @default.
• W2023440263 hasConcept C60987743 @default.
• W2023440263 hasConcept C62361671 @default.
• W2023440263 hasConcept C86803240 @default.
• W2023440263 hasConcept C89423630 @default.
• W2023440263 hasConceptScore W2023440263C104317684 @default.
• W2023440263 hasConceptScore W2023440263C118716 @default.
• W2023440263 hasConceptScore W2023440263C127716648 @default.

• next