FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023441058> ?p ?o ?g. }

• W2023441058 endingPage "e65126" @default.
• W2023441058 startingPage "e65126" @default.
• W2023441058 abstract "Background HIV infection has commonly been found to affect lipid profile and antioxidant defense. Objectives To determine the effects of Human Immunodeficiency Virus (HIV) infection and viral subtype on patient’s cholesterol and oxidative stress markers, and determine whether in the absence of Highly Active Antiretroviral Therapy (HAART), these biochemical parameters could be useful in patient’s management and monitoring disease progression in Cameroon. For this purpose, we measured total cholesterol (TC), LDL cholesterol (LDLC), HDL cholesterol (HDLC), total antioxidant ability (TAA), lipid peroxidation indices (LPI), and malondialdehyde (MDA) in HIV negative persons and HIV positive HAART-naïve patients infected with HIV-1 group M subtypes. Methods We measured serum TC, LDLC, HDLC, plasma MDA, and TAA concentrations, and calculated LPI indices in 151 HIV-positive HAART-naïve patients and 134 seronegative controls. We also performed gene sequence analysis on samples from 30 patients to determine the effect of viral genotypes on these biochemical parameters. We also determined the correlation between CD4 cell count and the above biochemical parameters. Results We obtained the following controls/patients values for TC (1.96±0.54/1. 12±0. 48 g/l), LDLC (0. 67±0. 46/0. 43±0. 36 g/l), HDLC (105. 51±28. 10/46. 54±23. 36 mg/dl) TAA (0. 63±0. 17/0. 16±0. 16 mM), MDA (0. 20±0. 07/0. 41±0. 10 µM) and LPI (0. 34±0. 14/26. 02±74. 40). In each case, the difference between the controls and patients was statistically significant (p<0.05). There was a positive and statistically significant Pearson correlation between CD4 cell count and HDLC (r = +0.272; p<0.01), TAA (r = +0.199; p<0.05) and a negative and statistically significant Pearson correlation between CD4 cell count and LPI (r = −0.166; p<0.05). Pearson correlation between CD4 cell count and TC, CD4cell count and LDLC was positive but not statistically significant while it was negative but not statistically significant with MDA. The different subtypes obtained after sequencing were CRF02_AG (43.3%), CRF01_AE (20%), A1 (23.3%), H (6.7%), and G (6.7%). None of the HIV-1 subtypes significantly influenced the levels of the biochemical parameters, but by grouping them as pure subtypes and circulating recombinant forms (CRFs), the CRF significantly influenced TC levels. TC was significantly lower in patients infected with CRF (0.87±0.27 g/l) compared to patients infected with pure HIV-1 subtypes (1.32±0.68 g/l) (p<0.017). MDA levels were also significantly higher in patients infected with HIV-1CRF01_AE (0.50±0.10 µM), compared to patients infected with CRF02_AG (0. 38±0. 08 µM) (p<0.018). Conclusion These results show that HIV infection in Cameroon is associated with significant decrease in TAA, LDLC, HDLC and TC, and increased MDA concentration and LPI indices which seem to be linked to the severity of HIV infection as assessed by CD4 cell count. The data suggests increased oxidative stress and lipid peroxidation in HIV-infected patients in Cameroon, and an influence of CRFs on TC and MDA levels." @default.
• W2023441058 created "2016-06-24" @default.
• W2023441058 creator A5008885845 @default.
• W2023441058 creator A5039373201 @default.
• W2023441058 creator A5050720946 @default.
• W2023441058 creator A5072090047 @default.
• W2023441058 creator A5076980268 @default.
• W2023441058 creator A5079328612 @default.
• W2023441058 creator A5086097861 @default.
• W2023441058 creator A5086774994 @default.
• W2023441058 date "2013-06-07" @default.
• W2023441058 modified "2023-10-17" @default.
• W2023441058 title "Lipid Peroxidation and Total Cholesterol in HAART-Naïve Patients Infected with Circulating Recombinant Forms of Human Immunodeficiency Virus Type-1 in Cameroon" @default.
• W2023441058 cites W1977705956 @default.
• W2023441058 cites W2004669329 @default.
• W2023441058 cites W2032952072 @default.
• W2023441058 cites W2048331100 @default.
• W2023441058 cites W2048789069 @default.
• W2023441058 cites W2065461553 @default.
• W2023441058 cites W2073977954 @default.
• W2023441058 cites W2106882534 @default.
• W2023441058 cites W2116404316 @default.
• W2023441058 cites W2128698112 @default.
• W2023441058 cites W2149765485 @default.
• W2023441058 cites W2152069819 @default.
• W2023441058 cites W2158666214 @default.
• W2023441058 cites W2335195348 @default.
• W2023441058 cites W4254275792 @default.
• W2023441058 cites W4328001064 @default.
• W2023441058 doi "https://doi.org/10.1371/journal.pone.0065126" @default.
• W2023441058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3676401" @default.
• W2023441058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23762297" @default.
• W2023441058 hasPublicationYear "2013" @default.
• W2023441058 type Work @default.
• W2023441058 sameAs 2023441058 @default.
• W2023441058 citedByCount "19" @default.
• W2023441058 countsByYear W20234410582014 @default.
• W2023441058 countsByYear W20234410582016 @default.
• W2023441058 countsByYear W20234410582019 @default.
• W2023441058 countsByYear W20234410582020 @default.
• W2023441058 countsByYear W20234410582021 @default.
• W2023441058 countsByYear W20234410582022 @default.
• W2023441058 countsByYear W20234410582023 @default.
• W2023441058 crossrefType "journal-article" @default.
• W2023441058 hasAuthorship W2023441058A5008885845 @default.
• W2023441058 hasAuthorship W2023441058A5039373201 @default.
• W2023441058 hasAuthorship W2023441058A5050720946 @default.
• W2023441058 hasAuthorship W2023441058A5072090047 @default.
• W2023441058 hasAuthorship W2023441058A5076980268 @default.
• W2023441058 hasAuthorship W2023441058A5079328612 @default.
• W2023441058 hasAuthorship W2023441058A5086097861 @default.
• W2023441058 hasAuthorship W2023441058A5086774994 @default.
• W2023441058 hasBestOaLocation W20234410581 @default.
• W2023441058 hasConcept C126322002 @default.
• W2023441058 hasConcept C203014093 @default.
• W2023441058 hasConcept C2776151105 @default.
• W2023441058 hasConcept C2778163477 @default.
• W2023441058 hasConcept C2778270857 @default.
• W2023441058 hasConcept C2778401633 @default.
• W2023441058 hasConcept C2780829032 @default.
• W2023441058 hasConcept C71924100 @default.
• W2023441058 hasConcept C90924648 @default.
• W2023441058 hasConceptScore W2023441058C126322002 @default.
• W2023441058 hasConceptScore W2023441058C203014093 @default.
• W2023441058 hasConceptScore W2023441058C2776151105 @default.
• W2023441058 hasConceptScore W2023441058C2778163477 @default.
• W2023441058 hasConceptScore W2023441058C2778270857 @default.
• W2023441058 hasConceptScore W2023441058C2778401633 @default.
• W2023441058 hasConceptScore W2023441058C2780829032 @default.
• W2023441058 hasConceptScore W2023441058C71924100 @default.
• W2023441058 hasConceptScore W2023441058C90924648 @default.
• W2023441058 hasIssue "6" @default.
• W2023441058 hasLocation W20234410581 @default.
• W2023441058 hasLocation W20234410582 @default.
• W2023441058 hasLocation W20234410583 @default.
• W2023441058 hasLocation W20234410584 @default.
• W2023441058 hasOpenAccess W2023441058 @default.
• W2023441058 hasPrimaryLocation W20234410581 @default.
• W2023441058 hasRelatedWork W1979639303 @default.
• W2023441058 hasRelatedWork W2070656560 @default.
• W2023441058 hasRelatedWork W2131352590 @default.
• W2023441058 hasRelatedWork W2538132594 @default.
• W2023441058 hasRelatedWork W2591522493 @default.
• W2023441058 hasRelatedWork W2741830417 @default.
• W2023441058 hasRelatedWork W2918895489 @default.
• W2023441058 hasRelatedWork W2952461587 @default.
• W2023441058 hasRelatedWork W2958374161 @default.
• W2023441058 hasRelatedWork W4301699110 @default.
• W2023441058 hasVolume "8" @default.
• W2023441058 isParatext "false" @default.
• W2023441058 isRetracted "false" @default.
• W2023441058 magId "2023441058" @default.
• W2023441058 workType "article" @default.