FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023441960> ?p ?o ?g. }

• W2023441960 endingPage "24" @default.
• W2023441960 startingPage "17" @default.
• W2023441960 abstract "ABSTRACT: Despite the potential relevance of the L-arginine-nitric oxide (NO) pathway in the pathophysiology of pulmonary hypertension, no in vivo studies of the kinetics of arginine and NO have been conducted previously in this population. The terminal guanidino N-atom of L-arginine is the precursor for NO, which is oxidized to the stable inorganic nitrogen oxides, nitrite (NO2-) and nitrate (NO3-). Thus, synthesized NO is detected in serum or urine as NO2- and NO3-. The purpose of this investigation was to compare studies of whole body arginine metabolism twice in nine patients with persistent pulmonary hypertension of the newborn (PPHN), using a primed constant i.v. infusion of L-[guanidino-15N2,5,52H2]arginine and L-[5,5,52H3]leucine, first during acute pulmonary vasoconstriction and again during convalescence, and thereby to characterize quantitative aspects of whole body arginine kinetics and NO production, as estimated from the rate of transfer of the 15N-guanidino-label of arginine to urinary nitrate (15NO3-). Arginine flux rates were 84.1 ± 8.6 μmol-kg.-1h-1 (mean ± SEM) during acute pulmonary hypertension and increased to 125 ± 13.2 (p < 0.05) during convalescence, whereas leucine fluxes were unchanged (168.5 ± 15 versus 178.8 ± 10.2 μmol.kg.-1h-1), and comparable to those reported in healthy newborns. During convalescence total urinary nitrate excreted increased by 66% (p < 0.05), urinary 15NO3- increased from 0.29 ± 0.07 to 0.74 ± 0.15 μmol.d-1 (p < 0.05), and the rate of plasma arginine conversion to NO increased from 10.3 ± 2.2 to 45.6 ± μmol.d-1 (p < 0.05). This study indicates a decreased plasma arginine utilization for whole body NO synthesis during the acute vasoconstrictive state of PPHN and suggests that arginine availability may become an important factor in NO formation." @default.
• W2023441960 created "2016-06-24" @default.
• W2023441960 creator A5039678062 @default.
• W2023441960 creator A5044793226 @default.
• W2023441960 creator A5050204175 @default.
• W2023441960 creator A5058901029 @default.
• W2023441960 creator A5060935755 @default.
• W2023441960 creator A5061970096 @default.
• W2023441960 creator A5071387327 @default.
• W2023441960 creator A5085244959 @default.
• W2023441960 creator A5088589795 @default.
• W2023441960 date "1995-07-01" @default.
• W2023441960 modified "2023-10-17" @default.
• W2023441960 title "Whole Body Arginine Metabolism and Nitric Oxide Synthesis in Newborns with Persistent Pulmonary Hypertension" @default.
• W2023441960 cites W1212704 @default.
• W2023441960 cites W147112024 @default.
• W2023441960 cites W1529433619 @default.
• W2023441960 cites W1555329455 @default.
• W2023441960 cites W1573977017 @default.
• W2023441960 cites W1802718746 @default.
• W2023441960 cites W1834041853 @default.
• W2023441960 cites W1964658642 @default.
• W2023441960 cites W1969310118 @default.
• W2023441960 cites W1970809760 @default.
• W2023441960 cites W1975982125 @default.
• W2023441960 cites W1979156656 @default.
• W2023441960 cites W1979236334 @default.
• W2023441960 cites W1981838142 @default.
• W2023441960 cites W1983875936 @default.
• W2023441960 cites W1990454697 @default.
• W2023441960 cites W1990802251 @default.
• W2023441960 cites W1995330034 @default.
• W2023441960 cites W2007375934 @default.
• W2023441960 cites W2010674902 @default.
• W2023441960 cites W2027223774 @default.
• W2023441960 cites W2038064947 @default.
• W2023441960 cites W2070308024 @default.
• W2023441960 cites W2081480546 @default.
• W2023441960 cites W2113387156 @default.
• W2023441960 cites W2118208213 @default.
• W2023441960 cites W2120872446 @default.
• W2023441960 cites W2132938670 @default.
• W2023441960 cites W2148550545 @default.
• W2023441960 cites W2158723969 @default.
• W2023441960 cites W2229199057 @default.
• W2023441960 cites W2249910312 @default.
• W2023441960 cites W2313326603 @default.
• W2023441960 cites W2331798828 @default.
• W2023441960 cites W2341304214 @default.
• W2023441960 cites W2394628017 @default.
• W2023441960 cites W2396981666 @default.
• W2023441960 cites W2399557568 @default.
• W2023441960 cites W88732903 @default.
• W2023441960 cites W2094104281 @default.
• W2023441960 cites W2585137949 @default.
• W2023441960 doi "https://doi.org/10.1203/00006450-199507000-00004" @default.
• W2023441960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7478791" @default.
• W2023441960 hasPublicationYear "1995" @default.
• W2023441960 type Work @default.
• W2023441960 sameAs 2023441960 @default.
• W2023441960 citedByCount "77" @default.
• W2023441960 countsByYear W20234419602012 @default.
• W2023441960 countsByYear W20234419602013 @default.
• W2023441960 countsByYear W20234419602014 @default.
• W2023441960 countsByYear W20234419602015 @default.
• W2023441960 countsByYear W20234419602016 @default.
• W2023441960 countsByYear W20234419602017 @default.
• W2023441960 countsByYear W20234419602019 @default.
• W2023441960 countsByYear W20234419602020 @default.
• W2023441960 countsByYear W20234419602022 @default.
• W2023441960 crossrefType "journal-article" @default.
• W2023441960 hasAuthorship W2023441960A5039678062 @default.
• W2023441960 hasAuthorship W2023441960A5044793226 @default.
• W2023441960 hasAuthorship W2023441960A5050204175 @default.
• W2023441960 hasAuthorship W2023441960A5058901029 @default.
• W2023441960 hasAuthorship W2023441960A5060935755 @default.
• W2023441960 hasAuthorship W2023441960A5061970096 @default.
• W2023441960 hasAuthorship W2023441960A5071387327 @default.
• W2023441960 hasAuthorship W2023441960A5085244959 @default.
• W2023441960 hasAuthorship W2023441960A5088589795 @default.
• W2023441960 hasBestOaLocation W20234419601 @default.
• W2023441960 hasConcept C126322002 @default.
• W2023441960 hasConcept C134018914 @default.
• W2023441960 hasConcept C178790620 @default.
• W2023441960 hasConcept C185592680 @default.
• W2023441960 hasConcept C2776179834 @default.
• W2023441960 hasConcept C2776384668 @default.
• W2023441960 hasConcept C2777468819 @default.
• W2023441960 hasConcept C2777945365 @default.
• W2023441960 hasConcept C2780026642 @default.
• W2023441960 hasConcept C2780930700 @default.
• W2023441960 hasConcept C515207424 @default.
• W2023441960 hasConcept C519581460 @default.
• W2023441960 hasConcept C55493867 @default.
• W2023441960 hasConcept C71924100 @default.
• W2023441960 hasConceptScore W2023441960C126322002 @default.
• W2023441960 hasConceptScore W2023441960C134018914 @default.
• W2023441960 hasConceptScore W2023441960C178790620 @default.

• next