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- W2023442275 abstract "Neoplastic cells in a lymph-node metastasis in a young boy with a mediastinal mass but as yet uninvolved marrow were studied in vitro for thymus (T cell) or bone-marrow-derived (B cell) markers. Evidence is presented that cells binding to sheep red blood-cells and immunoglobulin-bearing cells represent two distinct lymphocyte subpopulations, most probably T cells and B cells, respectively. Most of the cells from the metastatic tumour mass appeared neoplastic cytologically; 86% of these cells formed rosettes spontaneously with sheep red blood-cells, while only 9% of the cells had immunoglobulin determinants. Cytological examination of the rosettes revealed neoplastic appearing cells binding red blood-cells. These studies suggest that certain mediastinal tumours usually associated with leukæmic manifestations (Sternberg sarcoma) are of thymic origin." @default.
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- W2023442275 date "1973-01-01" @default.
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- W2023442275 title "CHARACTERISATION OF MALIGNANT MEDIASTINAL LYMPHOID NEOPLASM (STERNBERG SARCOMA) AS THYMIC IN ORIGIN" @default.
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- W2023442275 doi "https://doi.org/10.1016/s0140-6736(73)90469-8" @default.
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