Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023442308> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2023442308 endingPage "44" @default.
- W2023442308 startingPage "38" @default.
- W2023442308 abstract "Tumor necrosis factor alpha (TNFalpha) can trigger both cell survival and apoptosis. In the present study, from the flow cytometry results, we found that the prolonged-treatment of TNFalpha until 24 h, resulted apoptosis in AM-1 cells (ameloblastoma cell line). These results were confirmed by DAPI staining, which showed nuclear fragmentation feature of AM-1 cells under treatment of TNFalpha. Our further investigation using specific caspase inhibitors showed that caspase-3 played a crucial role in mediating TNFalpha-induced apoptosis in AM-1 cells. In addition, significant elevation of TNFalpha potential in inducing apoptosis was seen by applying LY294002, phosphatidylinositol-3-OH kinase (PI3K) inhibitor, or U0126, mitogen-activated extracellular-regulated kinase (MEK1/2) inhibitor, prior to the treatment of TNFalpha in AM-1 cells. These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting TNFalpha-induced Akt and p44/42 mitogen-activated protein kinase (MAPK) cell survival pathways." @default.
- W2023442308 created "2016-06-24" @default.
- W2023442308 creator A5017133102 @default.
- W2023442308 creator A5020834328 @default.
- W2023442308 creator A5040275418 @default.
- W2023442308 creator A5083874941 @default.
- W2023442308 creator A5085142320 @default.
- W2023442308 date "2006-01-01" @default.
- W2023442308 modified "2023-10-17" @default.
- W2023442308 title "Inhibition of Akt and MAPK pathways elevated potential of TNFα in inducing apoptosis in ameloblastoma" @default.
- W2023442308 cites W1535099280 @default.
- W2023442308 cites W1600417207 @default.
- W2023442308 cites W1963640415 @default.
- W2023442308 cites W1963749512 @default.
- W2023442308 cites W2002408013 @default.
- W2023442308 cites W2002503549 @default.
- W2023442308 cites W2011879633 @default.
- W2023442308 cites W2012126480 @default.
- W2023442308 cites W2029200430 @default.
- W2023442308 cites W2029334263 @default.
- W2023442308 cites W2042087846 @default.
- W2023442308 cites W2047482683 @default.
- W2023442308 cites W2078087720 @default.
- W2023442308 cites W2084243966 @default.
- W2023442308 cites W2094044390 @default.
- W2023442308 cites W2095439711 @default.
- W2023442308 cites W2110252008 @default.
- W2023442308 cites W2133506204 @default.
- W2023442308 cites W2166488783 @default.
- W2023442308 cites W4248242263 @default.
- W2023442308 doi "https://doi.org/10.1016/j.oraloncology.2005.04.011" @default.
- W2023442308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16140562" @default.
- W2023442308 hasPublicationYear "2006" @default.
- W2023442308 type Work @default.
- W2023442308 sameAs 2023442308 @default.
- W2023442308 citedByCount "12" @default.
- W2023442308 countsByYear W20234423082014 @default.
- W2023442308 countsByYear W20234423082015 @default.
- W2023442308 countsByYear W20234423082016 @default.
- W2023442308 countsByYear W20234423082017 @default.
- W2023442308 countsByYear W20234423082021 @default.
- W2023442308 countsByYear W20234423082022 @default.
- W2023442308 crossrefType "journal-article" @default.
- W2023442308 hasAuthorship W2023442308A5017133102 @default.
- W2023442308 hasAuthorship W2023442308A5020834328 @default.
- W2023442308 hasAuthorship W2023442308A5040275418 @default.
- W2023442308 hasAuthorship W2023442308A5083874941 @default.
- W2023442308 hasAuthorship W2023442308A5085142320 @default.
- W2023442308 hasConcept C17991360 @default.
- W2023442308 hasConcept C184235292 @default.
- W2023442308 hasConcept C185592680 @default.
- W2023442308 hasConcept C190283241 @default.
- W2023442308 hasConcept C203014093 @default.
- W2023442308 hasConcept C2777527632 @default.
- W2023442308 hasConcept C502942594 @default.
- W2023442308 hasConcept C55493867 @default.
- W2023442308 hasConcept C57074206 @default.
- W2023442308 hasConcept C75217442 @default.
- W2023442308 hasConcept C86554907 @default.
- W2023442308 hasConcept C86803240 @default.
- W2023442308 hasConcept C95444343 @default.
- W2023442308 hasConceptScore W2023442308C17991360 @default.
- W2023442308 hasConceptScore W2023442308C184235292 @default.
- W2023442308 hasConceptScore W2023442308C185592680 @default.
- W2023442308 hasConceptScore W2023442308C190283241 @default.
- W2023442308 hasConceptScore W2023442308C203014093 @default.
- W2023442308 hasConceptScore W2023442308C2777527632 @default.
- W2023442308 hasConceptScore W2023442308C502942594 @default.
- W2023442308 hasConceptScore W2023442308C55493867 @default.
- W2023442308 hasConceptScore W2023442308C57074206 @default.
- W2023442308 hasConceptScore W2023442308C75217442 @default.
- W2023442308 hasConceptScore W2023442308C86554907 @default.
- W2023442308 hasConceptScore W2023442308C86803240 @default.
- W2023442308 hasConceptScore W2023442308C95444343 @default.
- W2023442308 hasIssue "1" @default.
- W2023442308 hasLocation W20234423081 @default.
- W2023442308 hasLocation W20234423082 @default.
- W2023442308 hasOpenAccess W2023442308 @default.
- W2023442308 hasPrimaryLocation W20234423081 @default.
- W2023442308 hasRelatedWork W2038169799 @default.
- W2023442308 hasRelatedWork W2095479222 @default.
- W2023442308 hasRelatedWork W2362061149 @default.
- W2023442308 hasRelatedWork W2369199515 @default.
- W2023442308 hasRelatedWork W2789463326 @default.
- W2023442308 hasRelatedWork W2991456638 @default.
- W2023442308 hasRelatedWork W3030319632 @default.
- W2023442308 hasRelatedWork W4361817057 @default.
- W2023442308 hasRelatedWork W4382751572 @default.
- W2023442308 hasRelatedWork W78830601 @default.
- W2023442308 hasVolume "42" @default.
- W2023442308 isParatext "false" @default.
- W2023442308 isRetracted "false" @default.
- W2023442308 magId "2023442308" @default.
- W2023442308 workType "article" @default.