FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023442831> ?p ?o ?g. }

• W2023442831 endingPage "1575" @default.
• W2023442831 startingPage "1566" @default.
• W2023442831 abstract "Abstract Objective B cell depletion with the anti‐CD20 antibody rituximab has proven efficacy in patients with rheumatoid arthritis (RA). The effects on B cell homeostasis after repeated treatments and the relationship of certain B cell subsets to clinical response or relapse are currently not known. Methods In this open‐label study, 17 patients with RA refractory to standard therapy were treated with 1 cycle of rituximab. Of these 17 patients, 11 received a second cycle of rituximab therapy. Immunophenotyping was performed before therapy and during B cell recovery. Results Twelve of 17 patients showed a good European League Against Rheumatism response after receiving 1 cycle of rituximab therapy. At the time of B cell recovery, the IgD+,CD27+ memory B cell subset was significantly larger ( P = 0.019) in the nonresponder group. Within the group of 12 responders, 6 patients, whose disease was characterized by a significantly higher proportion of overall CD27+ memory B cells before therapy, experienced an early relapse (weeks 24–40 posttreatment). Eleven patients were re‐treated, again resulting in a good clinical response. B cell reconstitution followed a similar pattern after each cycle. The early reconstitution phase was characterized by immature CD38++,IgD+,CD10+ B cells, whereas the number of naive B cells increased continuously thereafter. The number of memory B cells was still reduced at the time of the second depletion but recovered to levels similar to those following the first cycle of therapy. Conclusion Data derived from repeated B lymphocyte depletion with rituximab in patients with RA suggest that analysis of certain memory B cell subsets provides information on efficacy, response, and late as well as early relapse, consistent with the conclusion that targeting memory B cells is a key to its mechanism of action." @default.
• W2023442831 created "2016-06-24" @default.
• W2023442831 creator A5061222341 @default.
• W2023442831 creator A5074627741 @default.
• W2023442831 creator A5086942556 @default.
• W2023442831 date "2008-05-31" @default.
• W2023442831 modified "2023-10-18" @default.
• W2023442831 title "Anti-CD20 therapy in patients with rheumatoid arthritis: Predictors of response and B cell subset regeneration after repeated treatment" @default.
• W2023442831 cites W1525177589 @default.
• W2023442831 cites W1675831178 @default.
• W2023442831 cites W1847270645 @default.
• W2023442831 cites W1852406183 @default.
• W2023442831 cites W1974369659 @default.
• W2023442831 cites W1989439264 @default.
• W2023442831 cites W1990426435 @default.
• W2023442831 cites W1998618256 @default.
• W2023442831 cites W2024644107 @default.
• W2023442831 cites W2063150581 @default.
• W2023442831 cites W2071499539 @default.
• W2023442831 cites W2077286174 @default.
• W2023442831 cites W2077570217 @default.
• W2023442831 cites W2090669047 @default.
• W2023442831 cites W2108787411 @default.
• W2023442831 cites W2109553594 @default.
• W2023442831 cites W2110177517 @default.
• W2023442831 cites W2118994799 @default.
• W2023442831 cites W2122507029 @default.
• W2023442831 cites W2134753241 @default.
• W2023442831 cites W2143580964 @default.
• W2023442831 cites W2144047233 @default.
• W2023442831 cites W2152348310 @default.
• W2023442831 cites W2157130851 @default.
• W2023442831 cites W2159106700 @default.
• W2023442831 cites W2163206714 @default.
• W2023442831 doi "https://doi.org/10.1002/art.23473" @default.
• W2023442831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18512772" @default.
• W2023442831 hasPublicationYear "2008" @default.
• W2023442831 type Work @default.
• W2023442831 sameAs 2023442831 @default.
• W2023442831 citedByCount "167" @default.
• W2023442831 countsByYear W20234428312012 @default.
• W2023442831 countsByYear W20234428312013 @default.
• W2023442831 countsByYear W20234428312014 @default.
• W2023442831 countsByYear W20234428312015 @default.
• W2023442831 countsByYear W20234428312016 @default.
• W2023442831 countsByYear W20234428312017 @default.
• W2023442831 countsByYear W20234428312018 @default.
• W2023442831 countsByYear W20234428312019 @default.
• W2023442831 countsByYear W20234428312020 @default.
• W2023442831 countsByYear W20234428312021 @default.
• W2023442831 countsByYear W20234428312022 @default.
• W2023442831 crossrefType "journal-article" @default.
• W2023442831 hasAuthorship W2023442831A5061222341 @default.
• W2023442831 hasAuthorship W2023442831A5074627741 @default.
• W2023442831 hasAuthorship W2023442831A5086942556 @default.
• W2023442831 hasBestOaLocation W20234428311 @default.
• W2023442831 hasConcept C10205521 @default.
• W2023442831 hasConcept C126322002 @default.
• W2023442831 hasConcept C159654299 @default.
• W2023442831 hasConcept C159912055 @default.
• W2023442831 hasConcept C18031839 @default.
• W2023442831 hasConcept C203014093 @default.
• W2023442831 hasConcept C2777575956 @default.
• W2023442831 hasConcept C2778453870 @default.
• W2023442831 hasConcept C2780653079 @default.
• W2023442831 hasConcept C28328180 @default.
• W2023442831 hasConcept C48010095 @default.
• W2023442831 hasConcept C54355233 @default.
• W2023442831 hasConcept C71924100 @default.
• W2023442831 hasConcept C86803240 @default.
• W2023442831 hasConcept C90924648 @default.
• W2023442831 hasConceptScore W2023442831C10205521 @default.
• W2023442831 hasConceptScore W2023442831C126322002 @default.
• W2023442831 hasConceptScore W2023442831C159654299 @default.
• W2023442831 hasConceptScore W2023442831C159912055 @default.
• W2023442831 hasConceptScore W2023442831C18031839 @default.
• W2023442831 hasConceptScore W2023442831C203014093 @default.
• W2023442831 hasConceptScore W2023442831C2777575956 @default.
• W2023442831 hasConceptScore W2023442831C2778453870 @default.
• W2023442831 hasConceptScore W2023442831C2780653079 @default.
• W2023442831 hasConceptScore W2023442831C28328180 @default.
• W2023442831 hasConceptScore W2023442831C48010095 @default.
• W2023442831 hasConceptScore W2023442831C54355233 @default.
• W2023442831 hasConceptScore W2023442831C71924100 @default.
• W2023442831 hasConceptScore W2023442831C86803240 @default.
• W2023442831 hasConceptScore W2023442831C90924648 @default.
• W2023442831 hasIssue "6" @default.
• W2023442831 hasLocation W20234428311 @default.
• W2023442831 hasLocation W20234428312 @default.
• W2023442831 hasOpenAccess W2023442831 @default.
• W2023442831 hasPrimaryLocation W20234428311 @default.
• W2023442831 hasRelatedWork W1969480819 @default.
• W2023442831 hasRelatedWork W2001794114 @default.
• W2023442831 hasRelatedWork W2017866273 @default.
• W2023442831 hasRelatedWork W2039226259 @default.
• W2023442831 hasRelatedWork W2049439131 @default.
• W2023442831 hasRelatedWork W2126167931 @default.
• W2023442831 hasRelatedWork W2182701989 @default.

• next