FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023443341> ?p ?o ?g. }

• W2023443341 endingPage "57" @default.
• W2023443341 startingPage "148" @default.
• W2023443341 abstract "Increased sympathetic stimulation is known to be arrhythmogenic. Likewise increased loading of the myocardium can directly generate arrhythmias. The interaction between the two on the electrophysiology of the myocardium has not been investigated before. We investigated the effect of dobutamine infusion on the shortening of the monophasic action potential duration secondary to increased loading. This was investigated during steady-state pacing and during an alteration in beat-to-beat interval in the form of a restitution curve.Pigs were anaesthetised and their hearts exposed. Monophasic action potentials and segment lengths were recorded from the anterior surface of the left ventricle. The loading of the ventricle was increased by transiently occluding the aorta. Steady-state pacing and a restitution curve were performed. Recordings were taken before and during dobutamine infusion.At steady state, increased loading of the heart shortened the monophasic action potential duration by a mean (+/- s.e.m.) of 4.0 (+/- 0.5) ms (P < 0.001). During dobutamine infusion this shortening of the monophasic action potential increased. Shortening of the action potential duration increased with the dose of dobutamine up to 10 micrograms/kg/min after which a plateau was reached. By comparison to control, dobutamine depressed the electrical restitution curve at short test pulse intervals did not significantly alter the plateau. Increased loading elevated the initial section of the electrical restitution curve at short test pulse intervals and depressed the plateau in both the control recordings and those taken during dobutamine infusion. Increased loading increased the amplitude of the supernormal phase of the electrical restitution curve in control recordings and those taken during dobutamine infusion. Sympathetic stimulation by dobutamine during the steady state potentiates the effect of mechanoelectric feedback on the myocardium. The effect on the restitution curve varies with test pulse interval. At short test pulse intervals the effect of sympathetic stimulation dominates with only minor antagonistic modification by increased loading. However, at longer test pulse intervals the effect of mechanoelectric feedback is equal to that of sympathetic stimulation and is synergistic with it.The mechanically induced changes we describe in the normal pig heart in situ are relatively small. However, they are in the right direction to possibly contribute to arrhythmia under pathological conditions where mechanical as well as electrophysiological inhomogeneity is prominent." @default.
• W2023443341 created "2016-06-24" @default.
• W2023443341 creator A5013914103 @default.
• W2023443341 creator A5017990064 @default.
• W2023443341 creator A5022653251 @default.
• W2023443341 creator A5082357590 @default.
• W2023443341 creator A5088363882 @default.
• W2023443341 date "1996-07-01" @default.
• W2023443341 modified "2023-09-26" @default.
• W2023443341 title "Sympathomimetic modulation of load-dependent changes in the action potential duration in the in situ porcine heart." @default.
• W2023443341 cites W1965209261 @default.
• W2023443341 cites W1973264910 @default.
• W2023443341 cites W1980702154 @default.
• W2023443341 cites W2000700283 @default.
• W2023443341 cites W2012972549 @default.
• W2023443341 cites W2020452164 @default.
• W2023443341 cites W2023869925 @default.
• W2023443341 cites W2039783771 @default.
• W2023443341 cites W2046395431 @default.
• W2023443341 cites W2054436561 @default.
• W2023443341 cites W2071526303 @default.
• W2023443341 cites W2085210853 @default.
• W2023443341 cites W2090828213 @default.
• W2023443341 cites W2091512539 @default.
• W2023443341 cites W2100635982 @default.
• W2023443341 cites W2117176106 @default.
• W2023443341 cites W2121456619 @default.
• W2023443341 cites W2130084285 @default.
• W2023443341 cites W2151358262 @default.
• W2023443341 cites W2266757440 @default.
• W2023443341 cites W2284182664 @default.
• W2023443341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8776412" @default.
• W2023443341 hasPublicationYear "1996" @default.
• W2023443341 type Work @default.
• W2023443341 sameAs 2023443341 @default.
• W2023443341 citedByCount "6" @default.
• W2023443341 countsByYear W20234433412015 @default.
• W2023443341 countsByYear W20234433412020 @default.
• W2023443341 crossrefType "journal-article" @default.
• W2023443341 hasAuthorship W2023443341A5013914103 @default.
• W2023443341 hasAuthorship W2023443341A5017990064 @default.
• W2023443341 hasAuthorship W2023443341A5022653251 @default.
• W2023443341 hasAuthorship W2023443341A5082357590 @default.
• W2023443341 hasAuthorship W2023443341A5088363882 @default.
• W2023443341 hasConcept C121332964 @default.
• W2023443341 hasConcept C126322002 @default.
• W2023443341 hasConcept C164705383 @default.
• W2023443341 hasConcept C17744445 @default.
• W2023443341 hasConcept C178853913 @default.
• W2023443341 hasConcept C185263204 @default.
• W2023443341 hasConcept C185592680 @default.
• W2023443341 hasConcept C189809214 @default.
• W2023443341 hasConcept C199539241 @default.
• W2023443341 hasConcept C24890656 @default.
• W2023443341 hasConcept C24998067 @default.
• W2023443341 hasConcept C2778392301 @default.
• W2023443341 hasConcept C2778921608 @default.
• W2023443341 hasConcept C2781185063 @default.
• W2023443341 hasConcept C42219234 @default.
• W2023443341 hasConcept C71924100 @default.
• W2023443341 hasConceptScore W2023443341C121332964 @default.
• W2023443341 hasConceptScore W2023443341C126322002 @default.
• W2023443341 hasConceptScore W2023443341C164705383 @default.
• W2023443341 hasConceptScore W2023443341C17744445 @default.
• W2023443341 hasConceptScore W2023443341C178853913 @default.
• W2023443341 hasConceptScore W2023443341C185263204 @default.
• W2023443341 hasConceptScore W2023443341C185592680 @default.
• W2023443341 hasConceptScore W2023443341C189809214 @default.
• W2023443341 hasConceptScore W2023443341C199539241 @default.
• W2023443341 hasConceptScore W2023443341C24890656 @default.
• W2023443341 hasConceptScore W2023443341C24998067 @default.
• W2023443341 hasConceptScore W2023443341C2778392301 @default.
• W2023443341 hasConceptScore W2023443341C2778921608 @default.
• W2023443341 hasConceptScore W2023443341C2781185063 @default.
• W2023443341 hasConceptScore W2023443341C42219234 @default.
• W2023443341 hasConceptScore W2023443341C71924100 @default.
• W2023443341 hasIssue "1" @default.
• W2023443341 hasLocation W20234433411 @default.
• W2023443341 hasOpenAccess W2023443341 @default.
• W2023443341 hasPrimaryLocation W20234433411 @default.
• W2023443341 hasRelatedWork W1968548770 @default.
• W2023443341 hasRelatedWork W2023443341 @default.
• W2023443341 hasRelatedWork W2054436561 @default.
• W2023443341 hasRelatedWork W2092630756 @default.
• W2023443341 hasRelatedWork W2167244631 @default.
• W2023443341 hasRelatedWork W2375703560 @default.
• W2023443341 hasRelatedWork W2379494380 @default.
• W2023443341 hasRelatedWork W2405821433 @default.
• W2023443341 hasRelatedWork W2891366938 @default.
• W2023443341 hasRelatedWork W2957491228 @default.
• W2023443341 hasVolume "32" @default.
• W2023443341 isParatext "false" @default.
• W2023443341 isRetracted "false" @default.
• W2023443341 magId "2023443341" @default.
• W2023443341 workType "article" @default.